Host Proviral and Antiviral Factors for SARS-CoV-2

Overview

Journal Virus Genes

Specialties Microbiology
Molecular Biology

Date 2021 Sep 12

PMID 34510331

Citations 7

Authors

Lu Lv

Leiliang Zhang

Affiliations

Soon will be listed here.

Abstract

Throughout the viral life cycle, interplays between cellular host factors and virus determine the infectious capacity of the virus. The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a great threat to human life and health. Extensive studies identified a number of host proviral and antiviral factors for SARS-CoV-2. In this review, we summarize the current understanding of the interplay between SARS-CoV-2 and cellular factors during virus entry and replication. Our review will highlight the future direction of study on the infection and pathogenesis of SARS-CoV-2, as well as novel therapeutic strategies and effective antiviral targets for COVID-19.

Citing Articles

Effect of Exportin 1/XPO1 Nuclear Export Pathway Inhibition on Coronavirus Replication.

Rahman M, Estifanos B, Glenn H, Gutierrez-Jensen A, Kibler K, Li Y Viruses. 2025; 17(2).

PMID: 40007039 PMC: 11860411. DOI: 10.3390/v17020284.

SARS-CoV-2 mechanisms of cell tropism in various organs considering host factors.

Behboudi E, Nooreddin Faraji S, Daryabor G, Hashemi S, Asadi M, Edalat F Heliyon. 2024; 10(4):e26577.

PMID: 38420467 PMC: 10901034. DOI: 10.1016/j.heliyon.2024.e26577.

Modulations in the host cell proteome by the hantavirus nucleocapsid protein.

Royster A, Ren S, Ali S, Mir S, Mir M PLoS Pathog. 2024; 20(1):e1011925.

PMID: 38190410 PMC: 10798635. DOI: 10.1371/journal.ppat.1011925.

Xuanfei Baidu decoction in the treatment of coronavirus disease 2019 (COVID-19): Efficacy and potential mechanisms.

Meng T, Ding J, Shen S, Xu Y, Wang P, Song X Heliyon. 2023; 9(9):e19163.

PMID: 37809901 PMC: 10558324. DOI: 10.1016/j.heliyon.2023.e19163.

The Isolation and In Vitro Differentiation of Primary Fetal Baboon Tracheal Epithelial Cells for the Study of SARS-CoV-2 Host-Virus Interactions.

Subramaniyan B, Gurung S, Bodas M, Moore A, Larabee J, Reuter D Viruses. 2023; 15(4).

PMID: 37112842 PMC: 10146425. DOI: 10.3390/v15040862.

References

Carette J, Raaben M, Wong A, Herbert A, Obernosterer G, Mulherkar N . Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature. 2011; 477(7364):340-3. PMC: 3175325. DOI: 10.1038/nature10348. View

Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S . SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020; 181(2):271-280.e8. PMC: 7102627. DOI: 10.1016/j.cell.2020.02.052. View

de Lartigue J, Polson H, Feldman M, Shokat K, Tooze S, Urbe S . PIKfyve regulation of endosome-linked pathways. Traffic. 2009; 10(7):883-93. PMC: 2723830. DOI: 10.1111/j.1600-0854.2009.00915.x. View

Braun E, Sauter D . Furin-mediated protein processing in infectious diseases and cancer. Clin Transl Immunology. 2019; 8(8):e1073. PMC: 6682551. DOI: 10.1002/cti2.1073. View

Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798):270-273. PMC: 7095418. DOI: 10.1038/s41586-020-2012-7. View

Luo J, Yang H, Song B . Mechanisms and regulation of cholesterol homeostasis. Nat Rev Mol Cell Biol. 2019; 21(4):225-245. DOI: 10.1038/s41580-019-0190-7. View

Wrapp D, Wang N, Corbett K, Goldsmith J, Hsieh C, Abiona O . Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020; 367(6483):1260-1263. PMC: 7164637. DOI: 10.1126/science.abb2507. View

Puelles V, Lutgehetmann M, Lindenmeyer M, Sperhake J, Wong M, Allweiss L . Multiorgan and Renal Tropism of SARS-CoV-2. N Engl J Med. 2020; 383(6):590-592. PMC: 7240771. DOI: 10.1056/NEJMc2011400. View

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H . Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020; 395(10224):565-574. PMC: 7159086. DOI: 10.1016/S0140-6736(20)30251-8. View

10.

Chen Z, Mi L, Xu J, Yu J, Wang X, Jiang J . Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus. J Infect Dis. 2005; 191(5):755-60. PMC: 7110046. DOI: 10.1086/427811. View

11.

Pfaender S, Mar K, Michailidis E, Kratzel A, Boys I, Vkovski P . LY6E impairs coronavirus fusion and confers immune control of viral disease. Nat Microbiol. 2020; 5(11):1330-1339. PMC: 7916999. DOI: 10.1038/s41564-020-0769-y. View

12.

Cantuti-Castelvetri L, Ojha R, Pedro L, Djannatian M, Franz J, Kuivanen S . Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020; 370(6518):856-860. PMC: 7857391. DOI: 10.1126/science.abd2985. View

13.

Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y . Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nat Commun. 2021; 12(1):134. PMC: 7794309. DOI: 10.1038/s41467-020-20457-w. View

14.

Bajimaya S, Frankl T, Hayashi T, Takimoto T . Cholesterol is required for stability and infectivity of influenza A and respiratory syncytial viruses. Virology. 2017; 510:234-241. PMC: 5571833. DOI: 10.1016/j.virol.2017.07.024. View

15.

Niv Y . Defensin 5 for prevention of SARS-CoV-2 invasion and Covid-19 disease. Med Hypotheses. 2020; 143:110244. PMC: 7471763. DOI: 10.1016/j.mehy.2020.110244. View

16.

Wang S, Qiu Z, Hou Y, Deng X, Xu W, Zheng T . AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. Cell Res. 2021; 31(2):126-140. PMC: 7791157. DOI: 10.1038/s41422-020-00460-y. View

17.

Jones D, Bevins C . Paneth cells of the human small intestine express an antimicrobial peptide gene. J Biol Chem. 1992; 267(32):23216-25. View

18.

Prescott E, Brimacombe C, Hartley M, Bell I, Graham S, Roberts S . Human papillomavirus type 1 E1^E4 protein is a potent inhibitor of the serine-arginine (SR) protein kinase SRPK1 and inhibits phosphorylation of host SR proteins and of the viral transcription and replication regulator E2. J Virol. 2014; 88(21):12599-611. PMC: 4248925. DOI: 10.1128/JVI.02029-14. View

19.

Lang C, Fellerer K, Schwenk B, Kuhn P, Kremmer E, Edbauer D . Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration. J Biol Chem. 2012; 287(23):19355-65. PMC: 3365973. DOI: 10.1074/jbc.M112.365098. View

20.

Hoffmann M, Kleine-Weber H, Pohlmann S . A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells. Mol Cell. 2020; 78(4):779-784.e5. PMC: 7194065. DOI: 10.1016/j.molcel.2020.04.022. View