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Role of Eyes and Eyes Protection Amidst SARS-CoV-2 Infection

Overview
Specialty General Medicine
Date 2021 Sep 11
PMID 34508449
Citations 3
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Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 pandemic has infected millions of people. The conjunctival epithelium is easily exposed to infectious droplets and body fluids making eyes a potential route and reservoir of the infection. The CD147 and ACE2 receptor has been demonstrated in ocular surface cells, which implies that these cells may facilitate as a portal of entry for transmission of Severe Acute Respiratory Syndrome Coronavirus 2. Despite low viral load in tears and conjunctival swab, the negative RT-PCR results cannot exclude the possibility of the presence of Severe Acute Respiratory Syndrome Coronavirus 2 in ocular secretions. Pathogens might be transported by constant tear flow through the lacrimal duct system to the respiratory tract causing infection. Eyes are unlikely to be the main transmission route, however, their role in the transmission of Severe Acute Respiratory Syndrome Coronavirus 2 cannot be overlooked. Therefore, proper eye protection should be instituted while attending Severe Acute Respiratory Syndrome Coronavirus 2 positive individuals, especially by health professionals.

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References
1.
Sun C, Wang Y, Liu G, Liu Z . Role of the Eye in Transmitting Human Coronavirus: What We Know and What We Do Not Know. Front Public Health. 2020; 8:155. PMC: 7193031. DOI: 10.3389/fpubh.2020.00155. View

2.
Belser J, Rota P, Tumpey T . Ocular tropism of respiratory viruses. Microbiol Mol Biol Rev. 2013; 77(1):144-56. PMC: 3591987. DOI: 10.1128/MMBR.00058-12. View

3.
Raboud J, Shigayeva A, McGeer A, Bontovics E, Chapman M, Gravel D . Risk factors for SARS transmission from patients requiring intubation: a multicentre investigation in Toronto, Canada. PLoS One. 2010; 5(5):e10717. PMC: 2873403. DOI: 10.1371/journal.pone.0010717. View

4.
Chen L, Liu M, Zhang Z, Qiao K, Huang T, Chen M . Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Br J Ophthalmol. 2020; 104(6):748-751. PMC: 7211077. DOI: 10.1136/bjophthalmol-2020-316304. View

5.
Chentoufi A, Dasgupta G, Nesburn A, Bettahi I, Binder N, Choudhury Z . Nasolacrimal duct closure modulates ocular mucosal and systemic CD4(+) T-cell responses induced following topical ocular or intranasal immunization. Clin Vaccine Immunol. 2010; 17(3):342-53. PMC: 2837957. DOI: 10.1128/CVI.00347-09. View