The Role of Mitochondrial Genes in Neurodegenerative Disorders

Overview

Journal Curr Neuropharmacol

Publisher Bentham Science Publishers

Date 2021 Sep 10

PMID 34503413

Citations 7

Authors

Rajesh Kumar

Seetha Harilal

Della Grace Thomas Parambi

S K Kanthlal

Md Atiar Rahman

Athanasios Alexiou

Gaber El-Saber Batiha

Bijo Mathew

Affiliations

Soon will be listed here.

Abstract

Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrial mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeable neuropathological lesions in postmortem samples. This review describes various gene mutations in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and stroke. These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mitochondrial dysfunctions due to either mtDNA mutation or deletion, the mechanism of which remains unclear in depth.

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