Photodynamic Therapy: A Compendium of Latest Reviews

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2021 Sep 10

PMID 34503255

Citations 62

Authors

Jose Francisco Algorri

Mario Ochoa

Pablo Roldan-Varona

Luis Rodriguez-Cobo

Jose Miguel Lopez-Higuera

Affiliations

Soon will be listed here.

Abstract

Photodynamic therapy (PDT) is a promising therapy against cancer. Even though it has been investigated for more than 100 years, scientific publications have grown exponentially in the last two decades. For this reason, we present a brief compendium of reviews of the last two decades classified under different topics, namely, overviews, reviews about specific cancers, and meta-analyses of photosensitisers, PDT mechanisms, dosimetry, and light sources. The key issues and main conclusions are summarized, including ways and means to improve therapy and outcomes. Due to the broad scope of this work and it being the first time that a compendium of the latest reviews has been performed for PDT, it may be of interest to a wide audience.

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References

Tampa M, Sarbu M, Matei C, Mitran C, Mitran M, Caruntu C . Photodynamic therapy: A hot topic in dermato-oncology. Oncol Lett. 2019; 17(5):4085-4093. PMC: 6444307. DOI: 10.3892/ol.2019.9939. View

Quon H, Grossman C, Finlay J, Zhu T, Clemmens C, Malloy K . Photodynamic therapy in the management of pre-malignant head and neck mucosal dysplasia and microinvasive carcinoma. Photodiagnosis Photodyn Ther. 2011; 8(2):75-85. PMC: 3598575. DOI: 10.1016/j.pdpdt.2011.01.001. View

Bhuvaneswari R, Gan Y, Soo K, Olivo M . The effect of photodynamic therapy on tumor angiogenesis. Cell Mol Life Sci. 2009; 66(14):2275-83. PMC: 11115708. DOI: 10.1007/s00018-009-0016-4. View

Castano A, Demidova T, Hamblin M . Mechanisms in photodynamic therapy: Part three-Photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction. Photodiagnosis Photodyn Ther. 2014; 2(2):91-106. PMC: 4108218. DOI: 10.1016/S1572-1000(05)00060-8. View

Griffin L, Lear J . Photodynamic Therapy and Non-Melanoma Skin Cancer. Cancers (Basel). 2016; 8(10). PMC: 5082388. DOI: 10.3390/cancers8100098. View

Hu L, Wang P, Zhao M, Liu L, Zhou L, Li B . Near-infrared rechargeable "optical battery" implant for irradiation-free photodynamic therapy. Biomaterials. 2018; 163:154-162. DOI: 10.1016/j.biomaterials.2018.02.029. View

Kawczyk-Krupka A, Bugaj A, Latos W, Zaremba K, Wawrzyniec K, Sieron A . Photodynamic therapy in colorectal cancer treatment: the state of the art in clinical trials. Photodiagnosis Photodyn Ther. 2015; 12(3):545-53. DOI: 10.1016/j.pdpdt.2015.04.004. View

Inoue K . 5-Aminolevulinic acid-mediated photodynamic therapy for bladder cancer. Int J Urol. 2017; 24(2):97-101. DOI: 10.1111/iju.13291. View

Panzarini E, Inguscio V, Dini L . Immunogenic cell death: can it be exploited in PhotoDynamic Therapy for cancer?. Biomed Res Int. 2013; 2013:482160. PMC: 3591131. DOI: 10.1155/2013/482160. View

10.

Nelke K, Pawlak W, Leszczyszyn J, Gerber H . Photodynamic therapy in head and neck cancer. Postepy Hig Med Dosw (Online). 2014; 68:119-28. DOI: 10.5604/17322693.1088044. View

11.

Parodi V, Jacchetti E, Osellame R, Cerullo G, Polli D, Raimondi M . Nonlinear Optical Microscopy: From Fundamentals to Applications in Live Bioimaging. Front Bioeng Biotechnol. 2020; 8:585363. PMC: 7581943. DOI: 10.3389/fbioe.2020.585363. View

12.

Anand S, Ortel B, Pereira S, Hasan T, Maytin E . Biomodulatory approaches to photodynamic therapy for solid tumors. Cancer Lett. 2012; 326(1):8-16. PMC: 3459352. DOI: 10.1016/j.canlet.2012.07.026. View

13.

Wilson B . Photodynamic therapy for cancer: principles. Can J Gastroenterol. 2002; 16(6):393-6. DOI: 10.1155/2002/743109. View

14.

Chiaviello A, Postiglione I, Palumbo G . Targets and mechanisms of photodynamic therapy in lung cancer cells: a brief overview. Cancers (Basel). 2013; 3(1):1014-41. PMC: 3756402. DOI: 10.3390/cancers3011014. View

15.

Hong E, Choi D, Shim M . Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials. Acta Pharm Sin B. 2016; 6(4):297-307. PMC: 4951583. DOI: 10.1016/j.apsb.2016.01.007. View

16.

Chen X, Song J, Chen X, Yang H . X-ray-activated nanosystems for theranostic applications. Chem Soc Rev. 2019; 48(11):3073-3101. DOI: 10.1039/c8cs00921j. View

17.

Bansal A, Yang F, Xi T, Zhang Y, Ho J . In vivo wireless photonic photodynamic therapy. Proc Natl Acad Sci U S A. 2018; 115(7):1469-1474. PMC: 5816188. DOI: 10.1073/pnas.1717552115. View

18.

Morton C . A synthesis of the world's guidelines on photodynamic therapy for non-melanoma skin cancer. G Ital Dermatol Venereol. 2018; 153(6):783-792. DOI: 10.23736/S0392-0488.18.05896-0. View

19.

Huang Y, Qiu F, Chen R, Yan D, Zhu X . Fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy. J Mater Chem B. 2020; 8(17):3772-3788. DOI: 10.1039/d0tb00262c. View

20.

Osuchowski M, Bartusik-Aebisher D, Osuchowski F, Aebisher D . Photodynamic therapy for prostate cancer - A narrative review. Photodiagnosis Photodyn Ther. 2020; 33:102158. DOI: 10.1016/j.pdpdt.2020.102158. View