NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases-Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Sep 10

PMID 34502425

Citations 14

Authors

Michal K Zarobkiewicz

Izabela Morawska

Adam Michalski

Jacek Rolinski

Agnieszka Bojarska-Junak

Affiliations

Soon will be listed here.

Abstract

NKT cells comprise three subsets-type I (invariant, iNKT), type II, and NKT-like cells, of which iNKT cells are the most studied subset. They are capable of rapid cytokine production after the initial stimulus, thus they may be important for polarisation of Th cells. Due to this, they may be an important cell subset in autoimmune diseases. In the current review, we are summarising results of NKT-oriented studies in major neurological autoimmune diseases-multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome and their corresponding animal models.

Citing Articles

Editorial: Neuroinflammatory aspects in neurological disorders.

Alipio P, Fabian L, Jorge G Front Mol Med. 2025; 5:1557546.

PMID: 40012853 PMC: 11850322. DOI: 10.3389/fmmed.2025.1557546.

The Absence of Thyroid-Stimulating Hormone Receptor Expression on Natural Killer T Cells: Implications for the Immune-Endocrine Interaction.

Adamska-Fita E, Sliwka P, Karbownik-Lewinska M, Lewinski A, Stasiak M Int J Mol Sci. 2024; 25(21).

PMID: 39518994 PMC: 11546653. DOI: 10.3390/ijms252111434.

Identification of immune subsets with distinct lectin binding signatures using multi-parameter flow cytometry: correlations with disease activity in systemic lupus erythematosus.

Szabo E, Farago A, Bodor G, Gemes N, Puskas L, Kovacs L Front Immunol. 2024; 15:1380481.

PMID: 38774868 PMC: 11106380. DOI: 10.3389/fimmu.2024.1380481.

A Humanized Mouse Model Coupled with Computational Analysis Identifies Potent Glycolipid Agonist of Invariant NKT Cells.

Saavedra-Avila N, Pigni N, Caldwell D, Chena-Becerra F, Intano Jr J, Ng T ACS Chem Biol. 2024; 19(4):926-937.

PMID: 38477945 PMC: 11075374. DOI: 10.1021/acschembio.3c00736.

Unremitting pro-inflammatory T-cell phenotypes, and macrophage activity, following paediatric burn injury.

Langley D, Zimmermann K, Krenske E, Stefanutti G, Kimble R, Holland A Clin Transl Immunology. 2024; 13(3):e1496.

PMID: 38463658 PMC: 10921233. DOI: 10.1002/cti2.1496.

References

Van de Keere F, Tonegawa S . CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J Exp Med. 1998; 188(10):1875-82. PMC: 2212404. DOI: 10.1084/jem.188.10.1875. View

Vandiedonck C, Giraud M, Garchon H . Genetics of autoimmune myasthenia gravis: the multifaceted contribution of the HLA complex. J Autoimmun. 2005; 25 Suppl:6-11. DOI: 10.1016/j.jaut.2005.09.010. View

Mars L, Laloux V, Goude K, Desbois S, Saoudi A, Van Kaer L . Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. J Immunol. 2002; 168(12):6007-11. DOI: 10.4049/jimmunol.168.12.6007. View

Araki M, Kondo T, Gumperz J, Brenner M, Miyake S, Yamamura T . Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission. Int Immunol. 2003; 15(2):279-88. DOI: 10.1093/intimm/dxg029. View

Yuki N, Hartung H . Guillain-Barré syndrome. N Engl J Med. 2012; 366(24):2294-304. DOI: 10.1056/NEJMra1114525. View

Mars L, Gautron A, Novak J, Beaudoin L, Diana J, Liblau R . Invariant NKT cells regulate experimental autoimmune encephalomyelitis and infiltrate the central nervous system in a CD1d-independent manner. J Immunol. 2008; 181(4):2321-9. DOI: 10.4049/jimmunol.181.4.2321. View

Zhu S, Zhang H, Bai L . NKT cells in liver diseases. Front Med. 2018; 12(3):249-261. DOI: 10.1007/s11684-018-0622-3. View

Leadbetter E, Karlsson M . Reading the room: iNKT cells influence B cell responses. Mol Immunol. 2020; 130:49-54. PMC: 7927200. DOI: 10.1016/j.molimm.2020.12.005. View

Bojarska-Junak A, Tabarkiewicz J, Rolinski J . [NKT cells: their development, mechanisms and effects of action]. Postepy Hig Med Dosw (Online). 2013; 67:65-78. DOI: 10.5604/17322693.1034001. View

10.

Wasnik S, Rundle C, Baylink D, Yazdi M, E Carreon E, Xu Y . 1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites. JCI Insight. 2018; 3(17). PMC: 6171806. DOI: 10.1172/jci.insight.98773. View

11.

Van Kaer L, Wu L . Therapeutic Potential of Invariant Natural Killer T Cells in Autoimmunity. Front Immunol. 2018; 9:519. PMC: 5859017. DOI: 10.3389/fimmu.2018.00519. View

12.

Lassmann H, Bradl M . Multiple sclerosis: experimental models and reality. Acta Neuropathol. 2016; 133(2):223-244. PMC: 5250666. DOI: 10.1007/s00401-016-1631-4. View

13.

Heming M, Schulte-Mecklenbeck A, Brix T, Wolbert J, Ruland T, Klotz L . Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights Into Inflammatory Neuropathies. Front Immunol. 2019; 10:515. PMC: 6448021. DOI: 10.3389/fimmu.2019.00515. View

14.

Godfrey D, Stankovic S, Baxter A . Raising the NKT cell family. Nat Immunol. 2010; 11(3):197-206. DOI: 10.1038/ni.1841. View

15.

Carr A, Cardwell C, McCarron P, McConville J . A systematic review of population based epidemiological studies in Myasthenia Gravis. BMC Neurol. 2010; 10:46. PMC: 2905354. DOI: 10.1186/1471-2377-10-46. View

16.

Schonbeck S, Padberg F, Hohlfeld R, Wekerle H . Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice. A new model of myasthenia gravis. J Clin Invest. 1992; 90(1):245-50. PMC: 443087. DOI: 10.1172/JCI115843. View

17.

Singh A, Wilson M, Hong S, Olivares-Villagomez D, Du C, Stanic A . Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J Exp Med. 2001; 194(12):1801-11. PMC: 2193577. DOI: 10.1084/jem.194.12.1801. View

18.

Bogdanos D, Smyk D, Invernizzi P, Rigopoulou E, Blank M, Pouria S . Infectome: a platform to trace infectious triggers of autoimmunity. Autoimmun Rev. 2012; 12(7):726-40. PMC: 7105216. DOI: 10.1016/j.autrev.2012.12.005. View

19.

Nair A, Patil-Chhablani P, Venkatramani D, Gandhi R . Ocular myasthenia gravis: a review. Indian J Ophthalmol. 2014; 62(10):985-91. PMC: 4278125. DOI: 10.4103/0301-4738.145987. View

20.

Wang Y, Jia J, Liu G, Wang Y . Research on the influence of α-GalCer activating experimental autoimmune myasthenia gravis mice NKT cells at different times on myasthenia gravis. J Biol Regul Homeost Agents. 2015; 29(1):195-200. View