Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Sep 10

PMID 34502277

Citations 8

Authors

Yeonggwon Jo

Seung Hyeon Hwang

Jinah Jang

Affiliations

Soon will be listed here.

Abstract

Tissues and organs are not composed of solely cellular components; instead, they converge with an extracellular matrix (ECM). The composition and function of the ECM differ depending on tissue types. The ECM provides a microenvironment that is essential for cellular functionality and regulation. However, during aging, the ECM undergoes significant changes along with the cellular components. The ECM constituents are over- or down-expressed, degraded, and deformed in senescence cells. ECM aging contributes to tissue dysfunction and failure of stem cell maintenance. Aging is the primary risk factor for prevalent diseases, and ECM aging is directly or indirectly correlated to it. Hence, rejuvenation strategies are necessitated to treat various age-associated symptoms. Recent rejuvenation strategies focus on the ECM as the basic biomaterial for regenerative therapies, such as tissue engineering. Modified and decellularized ECMs can be used to substitute aged ECMs and cell niches for culturing engineered tissues. Various tissue engineering approaches, including three-dimensional bioprinting, enable cell delivery and the fabrication of transplantable engineered tissues by employing ECM-based biomaterials.

Citing Articles

Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics.

Venkataraman A, Kordic I, Li J, Zhang N, Bharadwaj N, Fang Z NPJ Aging. 2024; 10(1):57.

PMID: 39592596 PMC: 11599402. DOI: 10.1038/s41514-024-00178-w.

The impact of the senescent microenvironment on tumorigenesis: Insights for cancer therapy.

Zhang W, Zhang K, Shi J, Qiu H, Kan C, Ma Y Aging Cell. 2024; 23(5):e14182.

PMID: 38650467 PMC: 11113271. DOI: 10.1111/acel.14182.

Getting physical: Material mechanics is an intrinsic cell cue.

Atcha H, Choi Y, Chaudhuri O, Engler A Cell Stem Cell. 2023; 30(6):750-765.

PMID: 37267912 PMC: 10247187. DOI: 10.1016/j.stem.2023.05.003.

Glioblastoma Microenvironment and Invasiveness: New Insights and Therapeutic Targets.

Erices J, Bizama C, Niechi I, Uribe D, Rosales A, Fabres K Int J Mol Sci. 2023; 24(8).

PMID: 37108208 PMC: 10139189. DOI: 10.3390/ijms24087047.

Aging microenvironment and antitumor immunity for geriatric oncology: the landscape and future implications.

Zhao B, Wu B, Feng N, Zhang X, Zhang X, Wei Y J Hematol Oncol. 2023; 16(1):28.

PMID: 36945046 PMC: 10032017. DOI: 10.1186/s13045-023-01426-4.

References

Godin L, Sandri B, Wagner D, Meyer C, Price A, Akinnola I . Decreased Laminin Expression by Human Lung Epithelial Cells and Fibroblasts Cultured in Acellular Lung Scaffolds from Aged Mice. PLoS One. 2016; 11(3):e0150966. PMC: 4783067. DOI: 10.1371/journal.pone.0150966. View

Longas M, Burden J, Lesniak J, Booth R, McPencow J, Park J . Hyaluronic acid N-deacetylase assay in whole skin. Biomacromolecules. 2003; 4(1):189-92. DOI: 10.1021/bm025718g. View

Zhang W, Mu H, Zhang A, Cui G, Chen H, Duan J . A decrease in moisture absorption-retention capacity of N-deacetylation of hyaluronic acid. Glycoconj J. 2012; 30(6):577-83. DOI: 10.1007/s10719-012-9457-3. View

Arteel G, Naba A . The liver matrisome - looking beyond collagens. JHEP Rep. 2020; 2(4):100115. PMC: 7330160. DOI: 10.1016/j.jhepr.2020.100115. View

Kwon S, Kwon Y, Lee T, Park G, Kim J . Recent advances in stem cell therapeutics and tissue engineering strategies. Biomater Res. 2019; 22:36. PMC: 6299977. DOI: 10.1186/s40824-018-0148-4. View

Unal A, West J . Synthetic ECM: Bioactive Synthetic Hydrogels for 3D Tissue Engineering. Bioconjug Chem. 2020; 31(10):2253-2271. DOI: 10.1021/acs.bioconjchem.0c00270. View

Bazrafshan Z, Stylios G . Spinnability of collagen as a biomimetic material: A review. Int J Biol Macromol. 2019; 129:693-705. DOI: 10.1016/j.ijbiomac.2019.02.024. View

Colognato H, Yurchenco P . Form and function: the laminin family of heterotrimers. Dev Dyn. 2000; 218(2):213-34. DOI: 10.1002/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO;2-R. View

Kumazaki T, Robetorye R, Robetorye S, Smith J . Fibronectin expression increases during in vitro cellular senescence: correlation with increased cell area. Exp Cell Res. 1991; 195(1):13-9. DOI: 10.1016/0014-4827(91)90494-f. View

10.

Vyborny K, Vallova J, Koci Z, Kekulova K, Jirakova K, Jendelova P . Genipin and EDC crosslinking of extracellular matrix hydrogel derived from human umbilical cord for neural tissue repair. Sci Rep. 2019; 9(1):10674. PMC: 6650505. DOI: 10.1038/s41598-019-47059-x. View

11.

Jeong H, Nam H, Jang J, Lee S . 3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs. Bioengineering (Basel). 2020; 7(2). PMC: 7357036. DOI: 10.3390/bioengineering7020032. View

12.

Nicolas J, Magli S, Rabbachin L, Sampaolesi S, Nicotra F, Russo L . 3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate. Biomacromolecules. 2020; 21(6):1968-1994. DOI: 10.1021/acs.biomac.0c00045. View

13.

Desai T, Shea L . Advances in islet encapsulation technologies. Nat Rev Drug Discov. 2016; 16(5):338-350. PMC: 11286215. DOI: 10.1038/nrd.2016.232. View

14.

Bai R, Tian L, Li Y, Zhang J, Wei Y, Jin Z . Combining ECM Hydrogels of Cardiac Bioactivity with Stem Cells of High Cardiomyogenic Potential for Myocardial Repair. Stem Cells Int. 2019; 2019:6708435. PMC: 6854924. DOI: 10.1155/2019/6708435. View

15.

Xing Q, Qian Z, Jia W, Ghosh A, Tahtinen M, Zhao F . Natural Extracellular Matrix for Cellular and Tissue Biomanufacturing. ACS Biomater Sci Eng. 2021; 3(8):1462-1476. DOI: 10.1021/acsbiomaterials.6b00235. View

16.

Kim J, Kim D, Lee H, Kim B, Kim Y . Atelocollagen Injection Improves Tendon Integrity in Partial-Thickness Rotator Cuff Tears: A Prospective Comparative Study. Orthop J Sports Med. 2020; 8(2):2325967120904012. PMC: 7036510. DOI: 10.1177/2325967120904012. View

17.

Majewski G, Rodan K, Fields K, Falla T . Characterization of bound water in skin hydrators prepared with and without a 3D3P interpenetrating polymer network. Skin Res Technol. 2018; 25(2):150-157. PMC: 7379968. DOI: 10.1111/srt.12624. View

18.

Papakonstantinou E, Roth M, Karakiulakis G . Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2013; 4(3):253-8. PMC: 3583886. DOI: 10.4161/derm.21923. View

19.

Lopez-Otin C, Blasco M, Partridge L, Serrano M, Kroemer G . The hallmarks of aging. Cell. 2013; 153(6):1194-217. PMC: 3836174. DOI: 10.1016/j.cell.2013.05.039. View

20.

Colcombe S, Erickson K, Raz N, Webb A, Cohen N, McAuley E . Aerobic fitness reduces brain tissue loss in aging humans. J Gerontol A Biol Sci Med Sci. 2003; 58(2):176-80. DOI: 10.1093/gerona/58.2.m176. View