Effects of Dietary Red Raspberry Consumption on Pre-Diabetes and Type 2 Diabetes Mellitus Parameters

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2021 Sep 10

PMID 34501954

Citations 12

Authors

Stefani A Derrick

Aleksandra S Kristo

Scott K Reaves

Angelos K Sikalidis

Affiliations

Soon will be listed here.

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition characterized by glucose clearance abnormalities and insufficient insulin response. Left uncontrolled, T2DM can result in serious complications and death. With no cure available currently and the prevalence of major risk factors such as pre-diabetes and the metabolic syndrome continuously increasing, there is an urgent need for effective treatments with limited or no side effects. Red raspberries (RR) contain various phytonutrients with potential for modulating insulin function, glucose, and lipid metabolism. The objective of this literature review was to investigate the potential metabolic benefits of dietary RR in individuals with T2DM and pre-diabetes. A search of major scientific databases was employed to identify peer-reviewed, in vivo, or human studies that utilized whole RR or its functional constituents as treatment. The studies examined provide evidence that RR may offer clinically beneficial effects for the prevention and management of chronic diseases through improvements in glucose handling and insulin sensitivity, adiposity, lipid profiles, ectopic lipid accumulation, inflammation, oxidative stress, and cardiac health. More human trials and in vivo studies are needed to confirm the benefits of dietary RR in T2DM and pre-diabetes and to explore the dose-dependent relationships, optimal duration, and treatment modality.

Citing Articles

Nutrients, Phytochemicals, and Antioxidant Capacity of Red Raspberry Nectar Fermented with .

Shi F, Qin Y, Qiu S, Luo Y Foods. 2024; 13(22).

PMID: 39594082 PMC: 11593764. DOI: 10.3390/foods13223666.

Effects of Gossypetin on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats.

Naidoo K, Khathi A Molecules. 2024; 29(18).

PMID: 39339405 PMC: 11434540. DOI: 10.3390/molecules29184410.

Chemical composition, pharmacological activity and development strategies of : A review.

Xiong X, Liu Z, Che X, Zhang X, Li X, Gao W Chin Herb Med. 2024; 16(3):313-326.

PMID: 39072206 PMC: 11283228. DOI: 10.1016/j.chmed.2024.01.007.

Nutritionally Important Pro-Health Active Ingredients and Antioxidant Properties of Fruits and Fruit Juice of Selected Biennial Fruiting L. Cultivars.

Chwil M, Matraszek-Gawron R, Kostryco M, Rozanska-Boczula M Pharmaceuticals (Basel). 2023; 16(12).

PMID: 38139824 PMC: 10747748. DOI: 10.3390/ph16121698.

Exploring the Antioxidant Potential of Blackberry and Raspberry Leaves: Phytochemical Analysis, Scavenging Activity, and In Vitro Polyphenol Bioaccessibility.

Varzaru I, Oancea A, Vlaicu P, Saracila M, Untea A Antioxidants (Basel). 2023; 12(12).

PMID: 38136244 PMC: 10740815. DOI: 10.3390/antiox12122125.

References

. 2. Classification and Diagnosis of Diabetes. Diabetes Care. 2016; 40(Suppl 1):S11-S24. DOI: 10.2337/dc17-S005. View

Grussu D, Stewart D, McDougall G . Berry polyphenols inhibit α-amylase in vitro: identifying active components in rowanberry and raspberry. J Agric Food Chem. 2011; 59(6):2324-31. DOI: 10.1021/jf1045359. View

Kshatriya D, Li X, Giunta G, Yuan B, Zhao D, Simon J . Phenolic-enriched raspberry fruit extract (Rubus idaeus) resulted in lower weight gain, increased ambulatory activity, and elevated hepatic lipoprotein lipase and heme oxygenase-1 expression in male mice fed a high-fat diet. Nutr Res. 2019; 68:19-33. PMC: 6823123. DOI: 10.1016/j.nutres.2019.05.005. View

Torronen R, Kolehmainen M, Sarkkinen E, Poutanen K, Mykkanen H, Niskanen L . Berries reduce postprandial insulin responses to wheat and rye breads in healthy women. J Nutr. 2013; 143(4):430-6. DOI: 10.3945/jn.112.169771. View

Psaltopoulou T, Panagiotakos D, Pitsavos C, Chrysochoou C, Detopoulou P, Skoumas J . Dietary antioxidant capacity is inversely associated with diabetes biomarkers: the ATTICA study. Nutr Metab Cardiovasc Dis. 2010; 21(8):561-7. DOI: 10.1016/j.numecd.2009.11.005. View

Yang L, Ling W, Du Z, Chen Y, Li D, Deng S . Effects of Anthocyanins on Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2017; 8(5):684-693. PMC: 5593100. DOI: 10.3945/an.116.014852. View

Burton-Freeman B, Sandhu A, Edirisinghe I . Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links. Adv Nutr. 2016; 7(1):44-65. PMC: 4717884. DOI: 10.3945/an.115.009639. View

Gonzalez-Barrio R, Edwards C, Crozier A . Colonic catabolism of ellagitannins, ellagic acid, and raspberry anthocyanins: in vivo and in vitro studies. Drug Metab Dispos. 2011; 39(9):1680-8. DOI: 10.1124/dmd.111.039651. View

Kristo A, Klimis-Zacas D, Sikalidis A . Protective Role of Dietary Berries in Cancer. Antioxidants (Basel). 2016; 5(4). PMC: 5187535. DOI: 10.3390/antiox5040037. View

10.

Harris M . The metabolic syndrome. Aust Fam Physician. 2013; 42(8):524-7. View

11.

. 9. Pharmacologic Approaches to Glycemic Treatment: . Diabetes Care. 2018; 42(Suppl 1):S90-S102. DOI: 10.2337/dc19-S009. View

12.

Vara A, Pinela J, Dias M, Petrovic J, Nogueira A, Sokovic M . Compositional Features of the "Kweli" Red Raspberry and Its Antioxidant and Antimicrobial Activities. Foods. 2020; 9(11). PMC: 7690723. DOI: 10.3390/foods9111522. View

13.

Noratto G, Chew B, Atienza L . Red raspberry (Rubus idaeus L.) intake decreases oxidative stress in obese diabetic (db/db) mice. Food Chem. 2017; 227:305-314. DOI: 10.1016/j.foodchem.2017.01.097. View

14.

Neveu V, Perez-Jimenez J, Vos F, Crespy V, du Chaffaut L, Mennen L . Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. Database (Oxford). 2010; 2010:bap024. PMC: 2860900. DOI: 10.1093/database/bap024. View

15.

Suvarna R, Shenoy R, Hadapad B, Nayak A . Effectiveness of polyherbal formulations for the treatment of type 2 Diabetes mellitus - A systematic review and meta-analysis. J Ayurveda Integr Med. 2021; 12(1):213-222. PMC: 8039362. DOI: 10.1016/j.jaim.2020.11.002. View

16.

Xing T, Kang Y, Xu X, Wang B, Du M, Zhu M . Raspberry Supplementation Improves Insulin Signaling and Promotes Brown-Like Adipocyte Development in White Adipose Tissue of Obese Mice. Mol Nutr Food Res. 2018; 62(5). DOI: 10.1002/mnfr.201701035. View

17.

Calvano A, Izuora K, Oh E, Ebersole J, Lyons T, Basu A . Dietary berries, insulin resistance and type 2 diabetes: an overview of human feeding trials. Food Funct. 2019; 10(10):6227-6243. PMC: 7202899. DOI: 10.1039/c9fo01426h. View

18.

Cheang K, Nguyen T, Karjane N, Salley K . Raspberry Leaf and Hypoglycemia in Gestational Diabetes Mellitus. Obstet Gynecol. 2016; 128(6):1421-1424. DOI: 10.1097/AOG.0000000000001757. View

19.

Zhao L, Zou T, Gomez N, Wang B, Zhu M, Du M . Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1. Nutr Diabetes. 2018; 8(1):39. PMC: 6026595. DOI: 10.1038/s41387-018-0049-6. View

20.

Saeedi P, Salpea P, Karuranga S, Petersohn I, Malanda B, Gregg E . Mortality attributable to diabetes in 20-79 years old adults, 2019 estimates: Results from the International Diabetes Federation Diabetes Atlas, 9 edition. Diabetes Res Clin Pract. 2020; 162:108086. DOI: 10.1016/j.diabres.2020.108086. View