Beneficial Effect of Successful Simultaneous Pancreas-Kidney Transplantation on Plasma Profile of Metalloproteinases in Type 1 Diabetes Mellitus Patients

Overview

Journal J Clin Med

Specialty General Medicine

Date 2021 Sep 10

PMID 34501247

Authors

Jerzy Chudek

Aureliusz Kolonko

Jacek Ziaja

Tomasz Francuz

Dorota Kaminska

Aleksander J Owczarek

Piotr Kuczera

Agata Kujawa-Szewieczek

Mariusz Kusztal

Adrian P Kowalik

Dominika Bozek-Pajak

Joanna Kluz

Piotr Choreza

Robert Krol

Magdalena Krajewska

Lech Cierpka

Andrzej Wiecek

Affiliations

Soon will be listed here.

Abstract

It is not fully elucidated whether the restoring of normal glucose metabolism after successful simultaneous pancreas-kidney transplantation (SPK) improves vascular wall morphology and function in type 1 diabetic (T1D) patients. Therefore, we compared arterial stiffness, assessed by pulse wave velocity (PWV), carotid intima-media thickness (IMT), and biomarkers of arterial wall calcification in T1D patients after SPK or kidney transplantation alone (KTA). In 39 SPK and 39 KTA adult patients of similar age, PWV, IMT, circulating matrix metalloproteinases (MMPs) and calcification biomarkers were assessed at median 83 months post transplantation. Additionally, carotid plaques were visualized and semi-qualitatively classified. Although PWV and IMT values were similar, the occurrence of atherosclerotic plaques (51.3 vs. 70.3%, < 0.01) and calcified lesions (35.9 vs. 64.9%, < 0.05) was lower in SPK patients. There were significantly lower concentrations of MMP-1, MMP-2, MMP-3, and osteocalcin in SPK subjects. Among the analyzed biomarkers, only logMMP-1, logMMP-2, and logMMP-3 concentrations were associated with log HbA. Multivariate stepwise backward regression analysis revealed that MMP-1 and MMP-3 variability were explained only by log HbA. Normal glucose metabolism achieved by SPK is followed by the favorable profile of circulating matrix metalloproteinases, which may reflect the vasoprotective effect of pancreas transplantation.

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