Two Lip Carcinomas Following Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report and Literature Review

Overview

Journal Int J Dent

Publisher Wiley

Specialty Dentistry

Date 2021 Sep 9

PMID 34497645

Authors

Nouha Dammak

Latifa Berrezouga

Manel Njima

Ines Lahouel

Mehdi Khemiss

Mohamed Ben Khelifa

Affiliations

Soon will be listed here.

Abstract

Background: Secondary solid cancers are severe complications in patients who have undergone allogeneic hematopoietic stem cell transplantation (AHSCT) for malignant and nonmalignant lymphohematopoietic diseases.

Objective: The aim of this work was to report a case of two lip carcinomas following AHSCT and to warn doctors about the importance of regular check-ups of patients who have received HSCT. . A 57-year-old man was referred by the dermatology department for the management of exophytic budding lesions on the lower lip evolving since 5 months. The patient was in complete remission following allogeneic bone marrow transplantation for acute myeloid leukemia since five years. Clinical and histological findings confirmed the diagnosis of a squamous cell carcinoma of the two lesions.

Conclusion: It is of paramount importance to seek an oral squamous cell carcinoma in the presence of persistent lesions in HSCT recipients.

References

Curtis R, Metayer C, Rizzo J, Socie G, Sobocinski K, Flowers M . Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study. Blood. 2005; 105(10):3802-11. PMC: 1895092. DOI: 10.1182/blood-2004-09-3411. View

Fall-Dickson J, Pavletic S, Mays J, Schubert M . Oral Complications of Chronic Graft-Versus-Host Disease. J Natl Cancer Inst Monogr. 2019; 2019(53). PMC: 6699578. DOI: 10.1093/jncimonographs/lgz007. View

Han A, Kuan E, Mallen-St Clair J, Alonso J, Arshi A, St John M . Epidemiology of Squamous Cell Carcinoma of the Lip in the United States: A Population-Based Cohort Analysis. JAMA Otolaryngol Head Neck Surg. 2016; 142(12):1216-1223. DOI: 10.1001/jamaoto.2016.3455. View

Montebugnoli L, Gissi D, Marchetti C, Foschini M . Multiple squamous cell carcinomas of the oral cavity in a young patient with graft-versus-host disease following allogenic bone marrow transplantation. Int J Oral Maxillofac Surg. 2010; 40(5):556-8. DOI: 10.1016/j.ijom.2010.11.008. View

Bradford C, Hoffman H, Wolf G, Carey T, Baker S, McClatchey K . Squamous carcinoma of the head and neck in organ transplant recipients: possible role of oncogenic viruses. Laryngoscope. 1990; 100(2 Pt 1):190-4. DOI: 10.1288/00005537-199002000-00016. View

Kolb H, Socie G, Duell T, Van Lint M, Tichelli A, Apperley J . Malignant neoplasms in long-term survivors of bone marrow transplantation. Late Effects Working Party of the European Cooperative Group for Blood and Marrow Transplantation and the European Late Effect Project Group. Ann Intern Med. 1999; 131(10):738-44. DOI: 10.7326/0003-4819-131-10-199911160-00004. View

Szeto C, Shek T, Lie A, Au W, Yuen A, Kwong Y . Squamous cell carcinoma of the tongue complicating chronic oral mucosal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2004; 77(2):200-2. DOI: 10.1002/ajh.20160. View

Curtis R, Rowlings P, Deeg H, Shriner D, Socie G, Travis L . Solid cancers after bone marrow transplantation. N Engl J Med. 1997; 336(13):897-904. DOI: 10.1056/NEJM199703273361301. View

Majhail N, Brazauskas R, Rizzo J, Sobecks R, Wang Z, Horowitz M . Secondary solid cancers after allogeneic hematopoietic cell transplantation using busulfan-cyclophosphamide conditioning. Blood. 2010; 117(1):316-22. PMC: 3037753. DOI: 10.1182/blood-2010-07-294629. View

10.

Katz J, Islam M, Bhattacharyya I, Sandow P, Moreb J . Oral squamous cell carcinoma positive for p16/human papilloma virus in post allogeneic stem cell transplantation: 2 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014; 118(3):e74-8. DOI: 10.1016/j.oooo.2014.05.025. View

11.

Otsubo H, Yokoe H, Miya T, Atsuta F, Miura N, Tanzawa H . Gingival squamous cell carcinoma in a patient with chronic graft-versus-host disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997; 84(2):171-4. DOI: 10.1016/s1079-2104(97)90065-2. View

12.

Kakei Y, Akashi M, Komatsubara H, Minamikawa T, Komori T . p16 overexpression in malignant and premalignant lesions of the oral and esophageal mucosa following allogeneic hematopoietic stem cell transplantation. Head Neck Oncol. 2012; 4:38. PMC: 3448523. DOI: 10.1186/1758-3284-4-38. View

13.

Martelin E, Volin L, Itala-Remes M, Niittyvuopio R, Lindstrom V, Heiskanen J . Incidence and risk factors of secondary cancers after allogeneic stem cell transplantation: analysis of a single centre cohort with a long follow-up. Bone Marrow Transplant. 2018; 54(2):334-337. DOI: 10.1038/s41409-018-0290-6. View

14.

Zhang L, Epstein J, Poh C, Berean K, Lam W, Zhang X . Comparison of HPV infection, p53 mutation and allelic losses in post-transplant and non-posttransplant oral squamous cell carcinomas. J Oral Pathol Med. 2002; 31(3):134-41. DOI: 10.1034/j.1600-0714.2002.310302.x. View

15.

Kibbi N, Suozzi K, Ko C, Leffell D . Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease. Dermatol Surg. 2019; 45(7):1002-1005. DOI: 10.1097/DSS.0000000000001706. View

16.

Jansisyanont P, Pazoki A, Ord R . Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi's anemia. J Oral Maxillofac Surg. 2000; 58(12):1454-7. DOI: 10.1053/joms.2000.19212. View

17.

Rizzo J, Curtis R, Socie G, Sobocinski K, Gilbert E, Landgren O . Solid cancers after allogeneic hematopoietic cell transplantation. Blood. 2008; 113(5):1175-83. PMC: 2635083. DOI: 10.1182/blood-2008-05-158782. View

18.

Shimoni A, Shem-Tov N, Chetrit A, Volchek Y, Tallis E, Avigdor A . Secondary malignancies after allogeneic stem-cell transplantation in the era of reduced-intensity conditioning; the incidence is not reduced. Leukemia. 2012; 27(4):829-35. DOI: 10.1038/leu.2012.299. View

19.

Shimada K, Yokozawa T, Atsuta Y, Kohno A, Maruyama F, Yano K . Solid tumors after hematopoietic stem cell transplantation in Japan: incidence, risk factors and prognosis. Bone Marrow Transplant. 2005; 36(2):115-21. DOI: 10.1038/sj.bmt.1705020. View

20.

Lishner M, Patterson B, Kandel R, Fyles G, Curtis J, Meharchand J . Cutaneous and mucosal neoplasms in bone marrow transplant recipients. Cancer. 1990; 65(3):473-6. DOI: 10.1002/1097-0142(19900201)65:3<473::aid-cncr2820650316>3.0.co;2-v. View