Role of Exercise in Preventing and Restoring Gut Dysbiosis in Patients with Inflammatory Bowel Diseases: A Review

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2021 Sep 9

PMID 34497433

Citations 11

Authors

Tilemachos Koutouratsas

Anastassios Philippou

George Kolios

Michael Koutsilieris

Maria Gazouli

Affiliations

Soon will be listed here.

Abstract

Inflammatory bowel diseases (IBD) include a spectrum of chronic inflammatory disorders of the gastrointestinal tract whose pathogenesis is yet to be elucidated. The intestinal microbiome has been studied as a causal component, with certain microbiotic alterations having been observed in subtypes of IBD. Physical exercise is a modulator of the intestinal microbiome, causing shifts in its composition that are partially corrective of those observed in IBD; furthermore, physical exercise may be beneficial in patients with certain IBD subtypes. This review studies the effects of physical exercise on the human gut microbiome while investigating pathophysiologic mechanisms that could explain physical activity's clinical effects on patients with IBD.

Citing Articles

Fucoidan from Enhances Exercise Performance and Increases the Abundance of Beneficial Gut Bacteria in Mice.

Yang C, Dwan C, Wimmer B, Wilson R, Johnson L, Caruso V Mar Drugs. 2024; 22(11).

PMID: 39590765 PMC: 11595500. DOI: 10.3390/md22110485.

Current Approaches to Prevent or Reverse Microbiome Dysbiosis in Chronic Inflammatory Rheumatic Diseases.

Nkeck J, Tchuisseu-Kwangoua A, Pelda A, Tamko W, Hamadjoda S, Essama D Mediterr J Rheumatol. 2024; 35(2):220-233.

PMID: 39211023 PMC: 11350408. DOI: 10.31138/mjr.240224.cap.

Diagnosis and Medical Treatment of Acute and Chronic Idiopathic Pouchitis in Inflammatory Bowel Disease.

Meianu C, Stroie T, Istratescu D, Preda C, Diculescu M Medicina (Kaunas). 2024; 60(6).

PMID: 38929596 PMC: 11205934. DOI: 10.3390/medicina60060979.

Nutrition interventions and clinical outcomes of pregnant women with gestational diabetes mellitus: More than meets the eye.

Sinha S, Nishant P, Sinha R, Morya A, Prasad R World J Diabetes. 2024; 15(1):126-128.

PMID: 38313850 PMC: 10835497. DOI: 10.4239/wjd.v15.i1.126.

Fatigue, Physical Activity, and Quality of Life in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study.

Qiao R, Zhou Y, Ding T, Jiang X Int J Gen Med. 2024; 17:49-58.

PMID: 38221940 PMC: 10785688. DOI: 10.2147/IJGM.S440652.

References

Bilski J, Mazur-Bialy A, Brzozowski B, Magierowski M, Zahradnik-Bilska J, Wojcik D . Can exercise affect the course of inflammatory bowel disease? Experimental and clinical evidence. Pharmacol Rep. 2016; 68(4):827-36. DOI: 10.1016/j.pharep.2016.04.009. View

Campbell S, Wisniewski P, Noji M, McGuinness L, Haggblom M, Lightfoot S . The Effect of Diet and Exercise on Intestinal Integrity and Microbial Diversity in Mice. PLoS One. 2016; 11(3):e0150502. PMC: 4783017. DOI: 10.1371/journal.pone.0150502. View

Cerda B, Perez M, Perez-Santiago J, Tornero-Aguilera J, Gonzalez-Soltero R, Larrosa M . Gut Microbiota Modification: Another Piece in the Puzzle of the Benefits of Physical Exercise in Health?. Front Physiol. 2016; 7:51. PMC: 4757670. DOI: 10.3389/fphys.2016.00051. View

Pedersini P, Turroni S, Villafane J . Gut microbiota and physical activity: Is there an evidence-based link?. Sci Total Environ. 2020; 727:138648. DOI: 10.1016/j.scitotenv.2020.138648. View

Munukka E, Ahtiainen J, Puigbo P, Jalkanen S, Pahkala K, Keskitalo A . Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women. Front Microbiol. 2018; 9:2323. PMC: 6178902. DOI: 10.3389/fmicb.2018.02323. View

Denou E, Marcinko K, Surette M, Steinberg G, Schertzer J . High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity. Am J Physiol Endocrinol Metab. 2016; 310(11):E982-93. PMC: 4935139. DOI: 10.1152/ajpendo.00537.2015. View

Weingarden A, Vaughn B . Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease. Gut Microbes. 2017; 8(3):238-252. PMC: 5479396. DOI: 10.1080/19490976.2017.1290757. View

Liang R, Zhang S, Peng X, Yang W, Xu Y, Wu P . Characteristics of the gut microbiota in professional martial arts athletes: A comparison between different competition levels. PLoS One. 2019; 14(12):e0226240. PMC: 6934331. DOI: 10.1371/journal.pone.0226240. View

Ticinesi A, Lauretani F, Tana C, Nouvenne A, Ridolo E, Meschi T . Exercise and immune system as modulators of intestinal microbiome: implications for the gut-muscle axis hypothesis. Exerc Immunol Rev. 2019; 25:84-95. View

10.

Cook M, Allen J, Pence B, Wallig M, Gaskins H, White B . Exercise and gut immune function: evidence of alterations in colon immune cell homeostasis and microbiome characteristics with exercise training. Immunol Cell Biol. 2015; 94(2):158-63. DOI: 10.1038/icb.2015.108. View

11.

Lamers C, de Roos N, Bongers C, Ten Haaf D, Hartman Y, Witteman B . Repeated prolonged moderate-intensity walking exercise does not appear to have harmful effects on inflammatory markers in patients with inflammatory bowel disease. Scand J Gastroenterol. 2020; 56(1):30-37. DOI: 10.1080/00365521.2020.1845791. View

12.

Cheifetz A, Gianotti R, Luber R, Gibson P . Complementary and Alternative Medicines Used by Patients With Inflammatory Bowel Diseases. Gastroenterology. 2016; 152(2):415-429.e15. DOI: 10.1053/j.gastro.2016.10.004. View

13.

Zhao X, Zhang Z, Hu B, Huang W, Yuan C, Zou L . Response of Gut Microbiota to Metabolite Changes Induced by Endurance Exercise. Front Microbiol. 2018; 9:765. PMC: 5920010. DOI: 10.3389/fmicb.2018.00765. View

14.

Estaki M, Morck D, Ghosh S, Quin C, Pither J, Barnett J . Physical Activity Shapes the Intestinal Microbiome and Immunity of Healthy Mice but Has No Protective Effects against Colitis in MUC2 Mice. mSystems. 2020; 5(5). PMC: 7542559. DOI: 10.1128/mSystems.00515-20. View

15.

Allen J, Miller M, Pence B, Whitlock K, Nehra V, Gaskins H . Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J mice. J Appl Physiol (1985). 2015; 118(8):1059-66. DOI: 10.1152/japplphysiol.01077.2014. View

16.

Engels M, Cross R, Long M . Exercise in patients with inflammatory bowel diseases: current perspectives. Clin Exp Gastroenterol. 2018; 11:1-11. PMC: 5743119. DOI: 10.2147/CEG.S120816. View

17.

Monda V, Villano I, Messina A, Valenzano A, Esposito T, Moscatelli F . Exercise Modifies the Gut Microbiota with Positive Health Effects. Oxid Med Cell Longev. 2017; 2017:3831972. PMC: 5357536. DOI: 10.1155/2017/3831972. View

18.

Cook M, Martin S, Williams C, Whitlock K, Wallig M, Pence B . Forced treadmill exercise training exacerbates inflammation and causes mortality while voluntary wheel training is protective in a mouse model of colitis. Brain Behav Immun. 2013; 33:46-56. PMC: 3775960. DOI: 10.1016/j.bbi.2013.05.005. View

19.

Donati Zeppa S, Agostini D, Gervasi M, Annibalini G, Amatori S, Ferrini F . Mutual Interactions among Exercise, Sport Supplements and Microbiota. Nutrients. 2019; 12(1). PMC: 7019274. DOI: 10.3390/nu12010017. View

20.

Veltkamp C, Tonkonogy S, de Jong Y, Albright C, Grenther W, Balish E . Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice. Gastroenterology. 2001; 120(4):900-13. DOI: 10.1053/gast.2001.22547. View