Phenotype and Pathological Significance of MCAM (CD146) T Cell Subset in Psoriatic Arthritis

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2021 Sep 7

PMID 34491483

Citations 2

Authors

Smriti K Raychaudhuri

Christine Abria

Siba P Raychaudhuri

Affiliations

Soon will be listed here.

Abstract

Background: CD146 (MCAM-melanoma cell adhesion molecule) is a cell surface adhesion molecule for Laminin 411. T cells expressing MCAM are mainly responsible for IL-17 production. IL-17 secreting T helper cells (Th17 cells) are critical for the pathogenesis of psoriatic arthritis (PsA). Here we hypothesized enrichment of CD146IL-17 memory T cells in PsA synovium and studied the association of CD146 expression and CD4IL-17 activated memory (CD11aCD45RO) T cells in synovial fluid and blood of PSA, rheumatoid arthritis (RA, a positive control) and osteoarthritis (OA) patients.

Methods: Hi-D FACS studies were done to identify IL-17 in CD4CD146CD45RO and CD8CD146CD45RO T cells.

Results: We observed that effector CD146(MCAM) T cells are enriched at the synovial inflammation site in PsA.

Conclusion: As CD146 T cells are a key resource for IL-17 it is likely that the enrichment of these MCAM pathologic cells are critical for the disease process of PsA.

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