The Effects of Vitamin D Supplementation in Carpal Tunnel Syndrome Treatment Outcomes: a Systematic Review

Overview

Journal J Exp Orthop

Publisher Wiley

Specialty Orthopedics

Date 2021 Sep 7

PMID 34490545

Citations 3

Authors

Chirathit Anusitviwat

Porames Suwanno

Sitthiphong Suwannaphisit

Affiliations

Soon will be listed here.

Abstract

Purpose: Vitamin D deficiency is related to carpal tunnel syndrome symptoms. Correcting vitamin D levels by supplementation was supposed to improve carpel tunnel symptoms, though there is a lack of aggregated data about treatment outcomes. This study aimed to examine whether vitamin D supplementation could improve the treatment outcomes in carpal tunnel syndrome patients.

Methods: A comprehensive search of the PubMed, Cochrane Library, Scopus, and Web of Science databases for articles on vitamin D and carpel tunnel syndrome from January 2000 to March 2021 was performed. The article screening and data extraction were performed by two investigators independently with blinding to decisions on selected studies. All included studies had assessed the quality of evidence using the Methodological Index for Non-Randomized Studies (MINORS) scoring system.

Results: We retrieved four studies that met the eligibility criteria. The treatment outcomes were evaluated by visual analog scale (124 wrists), functional scores (176 patients), muscle strength (84 patients), and nerve conduction velocity (216 wrists). After vitamin D supplementation, two studies reported improved pain scores and nerve conduction velocity, and three studies showed enhancement of functional status.

Conclusion: Vitamin D administration could offer favorable outcomes in pain improvement, better functional status, and increased sensory conduction velocity in carpal tunnel syndrome. However, there is to date no recommendations concerning a standardized dose or duration of vitamin D administration in carpal tunnel syndrome; prescribing vitamin D at the usual appropriate dose is suggested as an additional treatment in patients with mild to moderate carpel tunnel symptoms.

Level Of Evidence: Level IV, therapeutic study.

Citing Articles

The Role of Vitamin D in the Treatment of Carpal Tunnel Syndrome: Clinical and Electroneuromyographic Responses.

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Occupational and non-occupational risk factors correlating with the severity of clinical manifestations of carpal tunnel syndrome and related work disability among workers who work with a computer.

Cupi B, Sarac I, Jovanovic J, Jovanovic S, Petrovic-Oggiano G, Debeljak-Martacic J Arh Hig Rada Toksikol. 2023; 74(4):252-272.

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Bilateral carpal tunnel syndrome revealing an acromegaly: a case report.

Toulali F, Srifi H, Talbi D, Guerboub A Pan Afr Med J. 2023; 44:186.

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References

Faye P, Poumeaud F, Miressi F, Lia A, Demiot C, Magy L . Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System. Front Neurosci. 2019; 13:348. PMC: 6474301. DOI: 10.3389/fnins.2019.00348. View

Sacmaci H, Tanik N, Balbaloglu O, Akturk T, Inan L . Electrophysiological evaluation of carpal tunnel syndrome female patients after vitamin D replacement. Arq Neuropsiquiatr. 2020; 78(4):224-229. DOI: 10.1590/0004-282X20190193. View

Lee M, Gong H, Lee M, Cho K, Kim J, Baek G . The Effect of Vitamin D Deficiency Correction on the Outcomes in Women After Carpal Tunnel Release. J Hand Surg Am. 2019; 44(8):649-654. DOI: 10.1016/j.jhsa.2019.03.008. View

Ghasemi-Rad M, Nosair E, Vegh A, Mohammadi A, Akkad A, Lesha E . A handy review of carpal tunnel syndrome: From anatomy to diagnosis and treatment. World J Radiol. 2014; 6(6):284-300. PMC: 4072815. DOI: 10.4329/wjr.v6.i6.284. View

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. Open Med. 2011; 3(3):e123-30. PMC: 3090117. View

Tanik N, Balbaloglu O, Ucar M, Sarp U, Atalay T, Celikbilek A . Does vitamin D deficiency trigger carpal tunnel syndrome?. J Back Musculoskelet Rehabil. 2016; 29(4):835-839. DOI: 10.3233/BMR-160696. View

Newington L, Harris E, Walker-Bone K . Carpal tunnel syndrome and work. Best Pract Res Clin Rheumatol. 2015; 29(3):440-53. PMC: 4759938. DOI: 10.1016/j.berh.2015.04.026. View

Aroori S, Spence R . Carpal tunnel syndrome. Ulster Med J. 2008; 77(1):6-17. PMC: 2397020. View

Burton C, Chen Y, Chesterton L, van der Windt D . Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records. BMJ Open. 2018; 8(6):e020166. PMC: 6020969. DOI: 10.1136/bmjopen-2017-020166. View

10.

Ghai B, Bansal D, Kanukula R, Gudala K, Sachdeva N, Dhatt S . Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial. Pain Physician. 2017; 20(1):E99-E105. View

11.

Nageeb R, Shehta N, Nageeb G, Omran A . Body mass index and vitamin D level in carpal tunnel syndrome patients. Egypt J Neurol Psychiatr Neurosurg. 2018; 54(1):14. PMC: 5954785. DOI: 10.1186/s41983-018-0009-z. View

12.

Rejnmark L . Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials. Ther Adv Chronic Dis. 2012; 2(1):25-37. PMC: 3513873. DOI: 10.1177/2040622310381934. View

13.

Padua L, Coraci D, Erra C, Pazzaglia C, Paolasso I, Loreti C . Carpal tunnel syndrome: clinical features, diagnosis, and management. Lancet Neurol. 2016; 15(12):1273-1284. DOI: 10.1016/S1474-4422(16)30231-9. View

14.

Gruber H, Hoelscher G, Ingram J, Chow Y, Loeffler B, Hanley Jr E . 1,25(OH)2-vitamin D3 inhibits proliferation and decreases production of monocyte chemoattractant protein-1, thrombopoietin, VEGF, and angiogenin by human annulus cells in vitro. Spine (Phila Pa 1976). 2008; 33(7):755-65. DOI: 10.1097/BRS.0b013e3181695d59. View

15.

Lim K, Thadhani R . Vitamin D Toxicity. J Bras Nefrol. 2020; 42(2):238-244. PMC: 7427646. DOI: 10.1590/2175-8239-JBN-2019-0192. View

16.

Demiryurek B, Gundogdu A . The effect of vitamin D levels on pain in carpal tunnel syndrome. Orthop Traumatol Surg Res. 2017; 103(6):919-922. DOI: 10.1016/j.otsr.2017.05.003. View

17.

Basit A, Abdul Basit K, Fawwad A, Shaheen F, Fatima N, Petropoulos I . Vitamin D for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Res Care. 2016; 4(1):e000148. PMC: 4800070. DOI: 10.1136/bmjdrc-2015-000148. View

18.

Habib A, Nagi K, Thillaiappan N, Sukumaran V, Akhtar S . Vitamin D and Its Potential Interplay With Pain Signaling Pathways. Front Immunol. 2020; 11:820. PMC: 7270292. DOI: 10.3389/fimmu.2020.00820. View

19.

Malihi Z, Wu Z, Lawes C, Scragg R . Adverse events from large dose vitamin D supplementation taken for one year or longer. J Steroid Biochem Mol Biol. 2018; 188:29-37. DOI: 10.1016/j.jsbmb.2018.12.002. View

20.

Chabas J, Stephan D, Marqueste T, Garcia S, Lavaut M, Nguyen C . Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury. PLoS One. 2013; 8(5):e65034. PMC: 3669361. DOI: 10.1371/journal.pone.0065034. View