A Novel Azaphilone Muyophilone A From the Endophytic Fungus 0307-2

Overview

Journal Front Chem

Specialty Chemistry

Date 2021 Sep 7

PMID 34490216

Citations 1

Authors

Chao Yuan

Yuhua Guo

Ke Wang

Zhunian Wang

Longfei Li

Huajie Zhu

Gang Li

Affiliations

Soon will be listed here.

Abstract

Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid () and austdiol (), and their novel heterotrimer, muyophilone A (), were isolated and identified from an endophytic fungus, 0307-2. Their structures and stereochemistry were established by extensive spectroscopic analyses including HRMS, NMR spectroscopy, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectroscopic methods, as well as single crystal X-ray diffraction. In the structure of , two compound -derived azaphilone units were connected through an unprecedented five-membered carbon bridge which was proposed to be originated from compound . Compound represents the first example of azaphilone heterotrimers.

Citing Articles

Azaphilones produced by Penicillium maximae with their cell death-inducing activity on Adriamycin-treated cancer cell.

Matsumoto T, Ohnishi E, Kitagawa T, Okayama M, Saito Y, Yoshikawa H Genes Environ. 2023; 45(1):5.

PMID: 36658662 PMC: 9850696. DOI: 10.1186/s41021-023-00261-w.

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