Integrative Analysis of Minichromosome Maintenance Proteins and Their Prognostic Significance in Melanoma

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Sep 7

PMID 34490114

Citations 4

Authors

Wei Han

Yi-Zhu Wu

Xiao-Yu Zhao

Zhen-Hua Gong

Guo-Liang Shen

Affiliations

Soon will be listed here.

Abstract

Background: Minichromosome maintenance () is known for participating in cell cycle progression, as well as DNA replication. While the diverse expression patterns and prognostic values of s in melanoma still remained unclear.

Methods: In the present study, the transcriptional and clinical profiles of s were explored in patients with melanoma from multiple databases, including GEO, TCGA, ONCOMINE, GEPIA, UALCAN, cBioPortal, and TIMER databases.

Results: We found that the elevated expressions of and were significantly expressed in melanoma compared to normal skin. High mRNA levels of , , and were closely related to worse prognosis in patients with melanoma. GSEA showed hallmark pathways were most involved in mTORC1 signaling, G2M checkpoint, E2F targets, and mitotic spindle. Furthermore, we found potential correlations between the expression and the immune cell infiltration, including B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells.

Conclusion: Upregulated gene expression in melanoma probably played a crucial part in the development and progression of melanoma. The upregulated expressions could be used as potential prognostic markers to improve the poor outcome and prognostic accuracy in patients with melanoma. Our study might shed light on the selection of prognostic biomarkers as well as the underlying molecular pathogenesis of melanoma.

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