Quasi-cluster Randomized Trial of a Six-month Low-intensity Group-based Resistance Exercise for Hemodialysis Patients on Depression and Cognitive Function: a 12-month Follow-up

Overview

Journal Health Psychol Behav Med

Date 2021 Sep 6

PMID 34484975

Citations 4

Authors

Nanako Nakamura-Taira

Naoshi Horikawa

Fumie Oka

Yuri Igarashi

Sayaka Kobayashi

Shingo Kato

Takashi Enomoto

Hitomi Kimura

Yukari Watanabe

Toru Kumada

Kimihiko Matsuyama

Naoki Matsuoka

Haruo Yoshimasu

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to examine the effects of a six-month group-based low-intensity resistance exercise program on depression and the cognitive function of hemodialysis patients.

Method: We conducted a quasi-cluster randomized, open-label controlled study from October 2017 to December 2018. Forty-two patients undergoing hemodialysis completed the trial over six months; half participated in the resistance exercise group ( = 21, mean = 74.90 years of age, = 2.23, 66.67% female) and the other half were in a stretching control group ( = 21, mean = 72.57 years of age, SD = 2.26, 28.57% female). Depressive symptoms and cognitive function were the primary outcome measures. Behavioral and psychological problems associated with cognitive decline (NPI-Q), subjective insomnia, and exercise self-efficacy were secondary outcomes. Outcomes were measured at baseline, three-month (mid-intervention), six-month (end of intervention), and 12-month (six months after intervention) follow-ups. Linear mixed model analyses were used to determine short-term (immediately after intervention) and long-term (six months after intervention) effects.

Results: In depression, cognitive function, and the NPI-Q, there were no significant effects. In subjective insomnia, a short-term group-by-time interaction in the intervention group compared to the control group was found (ES = .43). However, the effect had disappeared by the 12-month follow-up. In exercise self-efficacy, short- and long-term group-by-time interactions were found. A significant short-term increase in the resistance exercise and a significant decrease in the stretching control was observed (ES = -.83). However, the effect was weakened in the long term (ES = -.38).

Conclusion: The results showed that low-intensity group resistance exercise would reduce subjective insomnia and improve exercise self-efficacy, but the effect was not maintained by six months after the program. This study was registered on the University Hospital Medical Information Network Clinical Trials Registry (UMIN000029372). UMIN Japan identifier: UMIN000029372.

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