GOLPH3 Keeps the Golgi Residents at Home
Overview
Overview
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
In this issue of JCB, Welch et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202106115) show that GOLPH3 mediates the sorting of numerous Golgi proteins into recycling COPI transport vesicles. This explains how many resident proteins are retained at the Golgi and reveals a key role for GOLPH3 in maintaining Golgi homeostasis.
Citing Articles
Khakurel A, Kudlyk T, Pokrovskaya I, DSouza Z, Lupashin V Front Cell Dev Biol. 2022; 10:1066504.
PMID: 36578782 PMC: 9791199. DOI: 10.3389/fcell.2022.1066504.
References
1.
Welch L, Munro S
. A tale of short tails, through thick and thin: investigating the sorting mechanisms of Golgi enzymes. FEBS Lett. 2019; 593(17):2452-2465.
DOI: 10.1002/1873-3468.13553.
View
2.
Welch L, Peak-Chew S, Begum F, Stevens T, Munro S
. GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles. J Cell Biol. 2021; 220(10).
PMC: 8421267.
DOI: 10.1083/jcb.202106115.
View
3.
Papanikou E, Glick B
. Golgi compartmentation and identity. Curr Opin Cell Biol. 2014; 29:74-81.
PMC: 4130901.
DOI: 10.1016/j.ceb.2014.04.010.
View
4.
Kuna R, Field S
. GOLPH3: a Golgi phosphatidylinositol(4)phosphate effector that directs vesicle trafficking and drives cancer. J Lipid Res. 2018; 60(2):269-275.
PMC: 6358304.
DOI: 10.1194/jlr.R088328.
View
5.
Schmitz K, Liu J, Li S, Gangi Setty T, Wood C, Burd C
. Golgi localization of glycosyltransferases requires a Vps74p oligomer. Dev Cell. 2008; 14(4):523-34.
PMC: 2707253.
DOI: 10.1016/j.devcel.2008.02.016.
View