The Differential Expression of Perilipin-2 in Hepatoblastoma and Its Association with Prognosis

Overview

Journal Histol Histopathol

Specialties Anatomy & Histology
Pathology

Date 2021 Sep 3

PMID 34477212

Citations 3

Authors

Sadafumi Azukisawa

Jianbo Zheng

Xin Guo

Hiroki Ura

Yo Niida

Tohru Itoh

Sohsuke Yamada

Affiliations

Soon will be listed here.

Abstract

Perilipin-2, a lipid droplet (LD) coating protein, has been found to be involved in cancer progression. However, its role in hepatoblastoma (HB) is undefined. We collected 87 HB samples and the corresponding clinical data. Immunohistochemistry (IHC) staining was performed to detect perilipin-2 and the association of the perilipin-2 expression with clinical characteristics and prognosis was analyzed. The expression of perilipin-2 was increased in fetal HB components in comparison to embryonal HB components. The predominant staining pattern was vesicular in fetal HB cells, while it was granular in embryonal HB cells. Furthermore, strong expression of perilipin-2 was associated with the histopathological type of fetal predominant HB. Although event-free survival (EFS) did not differ to a statistically significant extent between the strong and weak expression groups in a univariate survival analysis, a multivariate survival analysis revealed that EFS was significantly improved in the strong perilipin-2 expression group. In conclusion, perilipin-2 is differentially expressed in HB and the strong expression of perilipin-2 predicts a better prognosis.

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