Guiding Significance of Intraoperative Frozen Section for Range of Judging Incisal Edge of Esophageal Carcinoma

Overview

Journal Pak J Med Sci

Specialty General Medicine

Date 2021 Sep 3

PMID 34475937

Citations 1

Authors

Fei He

Chen Wang

Weichao Liu

Gongning Shi

Affiliations

Soon will be listed here.

Abstract

Objective: To explore guiding significance of intraoperative frozen section for judging incisal edge range of esophageal carcinoma.

Methods: A retrospective descriptive research design was used to collect the clinical and pathological data of 205 patients with esophageal cancer who were treated in Huaihe Hospital of Henan University from March 2012 to July 2015. Among them, 46 patients' esophageal margins were made into intraoperative frozen sections.

Results: In the 205 cases, nine cases were diagnoses with upper incisal edge cancerization, accounting for 4.39%, and five cases were diagnosed with lower incisal edge cancerization, accounting for 2.4%. There were 14 cases in total, accounting for 6.83%. four cases showed positive residual end of intraoperative frozen section.

Conclusion: The cancerous focus residue of incisal edge in esophageal carcinoma is not uncommon. Intraoperative frozen section is helpful to judge the proper excision length of esophageal carcinoma.

Citing Articles

Epidemiological and clinical characteristics of esophageal carcinoma: An experience from tertiary care hospital of Karachi, Pakistan.

Butt N, Soomro S, Haider G, Zehra A Pak J Med Sci. 2024; 40(1Part-I):55-59.

PMID: 38196475 PMC: 10772445. DOI: 10.12669/pjms.40.1.7419.

References

Kennedy N, Sebastian A, Thomas D, Thomas A, Gupta M, Kumar R . Diagnostic Accuracy of Frozen Section and Its Influence on Intraoperative Management of Indeterminate Epithelial Ovarian Tumors. Indian J Surg Oncol. 2019; 10(2):268-273. PMC: 6527664. DOI: 10.1007/s13193-018-00869-3. View

. Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer. 2011; 14(2):113-23. DOI: 10.1007/s10120-011-0042-4. View

Dexter S, Sue-Ling H, McMahon M, Quirke P, Mapstone N, Martin I . Circumferential resection margin involvement: an independent predictor of survival following surgery for oesophageal cancer. Gut. 2001; 48(5):667-70. PMC: 1728263. DOI: 10.1136/gut.48.5.667. View

Wu J, Chen Q, Teng L, Krasna M . Prognostic significance of positive circumferential resection margin in esophageal cancer: a systematic review and meta-analysis. Ann Thorac Surg. 2013; 97(2):446-53. DOI: 10.1016/j.athoracsur.2013.10.043. View

Evans R, Bundred J, Kaur P, Hodson J, Griffiths E . Meta-analysis of the influence of a positive circumferential resection margin in oesophageal cancer. BJS Open. 2019; 3(5):595-605. PMC: 6773635. DOI: 10.1002/bjs5.50183. View

Qureshi Y, Sarker S, Walker R, Hughes S . Proximal Resection Margin in Ivor-Lewis Oesophagectomy for Cancer. Ann Surg Oncol. 2016; 24(2):569-577. DOI: 10.1245/s10434-016-5510-y. View

Lai S, Masir N, Md Pauzi S . Intraoperative frozen section sentinel lymph node assessment in breast cancer: A tertiary institution experience. Malays J Pathol. 2018; 40(2):121-128. View

Knight W, Yip C, Wulaningsih W, Jacques A, Griffin N, Zylstra J . Prediction of a positive circumferential resection margin at surgery following neoadjuvant chemotherapy for adenocarcinoma of the oesophagus. BJS Open. 2019; 3(6):767-776. PMC: 6887675. DOI: 10.1002/bjs5.50211. View

Pultrum B, Honing J, Smit J, van Dullemen H, van Dam G, Groen H . A critical appraisal of circumferential resection margins in esophageal carcinoma. Ann Surg Oncol. 2009; 17(3):812-20. PMC: 2820690. DOI: 10.1245/s10434-009-0827-4. View

10.

Schmidt H, Gisbertz S, Moons J, Rouvelas I, Kauppi J, Brown A . Defining Benchmarks for Transthoracic Esophagectomy: A Multicenter Analysis of Total Minimally Invasive Esophagectomy in Low Risk Patients. Ann Surg. 2017; 266(5):814-821. DOI: 10.1097/SLA.0000000000002445. View

11.

Birbeck K, Macklin C, Tiffin N, Parsons W, Dixon M, Mapstone N . Rates of circumferential resection margin involvement vary between surgeons and predict outcomes in rectal cancer surgery. Ann Surg. 2002; 235(4):449-57. PMC: 1422458. DOI: 10.1097/00000658-200204000-00001. View

12.

Shapiro J, Biermann K, van Klaveren D, Offerhaus G, Ten Kate F, Meijer S . Prognostic Value of Pretreatment Pathological Tumor Extent in Patients Treated With Neoadjuvant Chemoradiotherapy Plus Surgery for Esophageal or Junctional Cancer. Ann Surg. 2017; 265(2):356-362. DOI: 10.1097/SLA.0000000000001630. View

13.

Shiraki T, Kuroda H, Takada A, Nakazato Y, Kubota K, Imai Y . Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma. World J Gastroenterol. 2018; 24(12):1332-1342. PMC: 5871828. DOI: 10.3748/wjg.v24.i12.1332. View

14.

Huang K, Wu Y, Chang W . Surgical treatment of carcinoma of the esophagus and gastric cardia. Chin Med J. 1963; 82:197-201. View

15.

INBERG M, Markkanen T, Scheinin T, Harri J . Absorption studies after excisional surgery of esophageal and high gastric carcinoma. Acta Chir Scand. 1970; 136(6):509-16. View

16.

Zhu Z, Li Z, He Z, Wang Y . [Endoscopic trans-fistula drainage for gastroesophageal anastomotic fistula with para-fistula abscess after esophagectomy]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2018; 46(6):637-642. PMC: 10396874. DOI: 10.3785/j.issn.1008-9292.2017.12.10. View

17.

Busweiler L, Wijnhoven B, van Berge Henegouwen M, Henneman D, van Grieken N, Wouters M . Early outcomes from the Dutch Upper Gastrointestinal Cancer Audit. Br J Surg. 2016; 103(13):1855-1863. DOI: 10.1002/bjs.10303. View

18.

Davarzani N, Hutchins G, West N, Hewitt L, Nankivell M, Cunningham D . Prognostic value of pathological lymph node status and primary tumour regression grading following neoadjuvant chemotherapy - results from the MRC OE02 oesophageal cancer trial. Histopathology. 2018; 72(7):1180-1188. PMC: 5969086. DOI: 10.1111/his.13491. View