Ion Channels in Bone Morphogenetic Protein Signaling

Overview

Journal Bioelectricity

Specialty Biology

Date 2021 Sep 2

PMID 34471808

Citations 2

Authors

Laura Faith George

Trevor Isner

Emily Anne Bates

Affiliations

Soon will be listed here.

Abstract

How a single fertilized egg develops into a complex multicellular organism is one of the great mysteries of life. Developmental biology textbooks describe cascades of ligands, receptors, kinases, and transcription factors that designate proliferation, migration, and ultimately fate of cells organized into a multicellular organism. Recently, it has become apparent that ion channels are integral to the process of developmental signaling. Ion channels provide bioelectric signals that must intersect with the known developmental signaling pathways. We review some evidence that bioelectric signaling contributes to bone morphogenetic protein signaling.

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