A Review on Current Research Status of the Surface Modification of Zn-based Biodegradable Metals

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2021 Sep 1

PMID 34466727

Citations 30

Authors

Wei Yuan

Dandan Xia

Shuilin Wu

Yufeng Zheng

Zhenpeng Guan

Julietta V Rau

Affiliations

Soon will be listed here.

Abstract

Recently, zinc and its alloys have been proposed as promising candidates for biodegradable metals (BMs), owning to their preferable corrosion behavior and acceptable biocompatibility in cardiovascular, bone and gastrointestinal environments, together with Mg-based and Fe-based BMs. However, there is the desire for surface treatment for Zn-based BMs to better control their biodegradation behavior. Firstly, the implantation of some Zn-based BMs in cardiovascular environment exhibited intimal activation with mild inflammation. Secondly, for orthopedic applications, the biodegradation rates of Zn-based BMs are relatively slow, resulting in a long-term retention after fulfilling their mission. Meanwhile, excessive Zn release during degradation will cause cytotoxicity and delayed osseointegration. In this review, we firstly summarized the current surface modification methods of Zn-based alloys for the industrial applications. Then we comprehensively summarized the recent progress of biomedical bulk Zn-based BMs as well as the corresponding surface modification strategies. Last but not least, the future perspectives towards the design of surface bio-functionalized coatings on Zn-based BMs for orthopedic and cardiovascular applications were also briefly proposed.

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