Exploring the Therapeutic Potential of Synthesized Cobalt Oxide (CoO-NPs) and Magnesium Oxide Nanoparticles (MgO-NPs)

Herein, we present a green, economic and ecofriendly protocol for synthesis of cobalt oxide (CoO-NPs) and magnesium oxide nanoparticles (MgO-NPs) for multifaceted biomedical applications. In the study, a simple aqueous leaf extract of was employed for the facile one pot synthesis of CoO-NPs and MgO-NPs. The well characterized NPs were explored for multiple biomedical applications including bactericidal activity against urinary tract infection (UTI) isolates, leishmaniasis, larvicidal, antidiabetic antioxidant and biocompatibility studies. Our results showed that both the NPs were highly active against multidrug resistant UTI isolates as compared to traditional antibiotics and induced significant zone of inhibition against The NPs, in particular CoO-NPs also showed significant larvicidal activity against the the mosquitoes involve in the transmission of Dengue fever. Similarly, excellent leishmanicidal activity was also observed against both the promastigote and amastigote forms of the parasite. Furthermore, the particles also exhibited considerable antidiabetic activity by inhibiting α-amylase and α-glucosidase enzymes. The biosynthesized NPs were found to be excellent antioxidant and biocompatible nanomaterials. Owing to ecofriendly synthesis, non-toxic and biocompatible nature, the synthesized CoO-NPs and MgO-NPs can be exploited as potential candidates for multiple biomedical applications.