Neurocutaneous Melanocytosis-associated Malignant Melanoma Presenting with Peritoneal Seeding

Overview

Journal Pediatr Dermatol

Publisher Wiley

Specialties Dermatology
Pediatrics

Date 2021 Aug 31

PMID 34463389

Citations 1

Authors

Ugur Sener

Kevin Elmore

Keerthana Jayaseelan

Joanne Porter

Ashfaq Marghoob

Marc K Rosenblum

Sofia Haque

Yasmin Khakoo

Affiliations

Soon will be listed here.

Abstract

Neurocutaneous melanocytosis (NCM) is characterized by melanocyte deposition in the leptomeninges and brain parenchyma, primarily occurring in children with large or giant congenital melanocytic nevi (LCMN) or multiple congenital melanocytic nevi. Patients with NCM may develop hydrocephalus and increased intracranial pressure, which can be managed with ventriculoperitoneal (VP) shunting. We present the case of a 16-month-old girl who developed peritoneal carcinomatosis and malignant ascites following VP shunting for hydrocephalus secondary to NCM to increase awareness of this rare, but serious, complication of cerebrospinal fluid diversion.

Citing Articles

Proton craniospinal irradiation with bevacizumab and pembrolizumab for leptomeningeal disease: a case report.

Webb M, Breen W, Laack N, Leventakos K, Campian J, Sener U CNS Oncol. 2023; 12(3):CNS101.

PMID: 37491842 PMC: 10410687. DOI: 10.2217/cns-2023-0005.

References

Narayan A, Jallo G, Huisman T . Extracranial, peritoneal seeding of primary malignant brain tumors through ventriculo-peritoneal shunts in children: Case report and review of the literature. Neuroradiol J. 2015; 28(5):536-9. PMC: 4757229. DOI: 10.1177/1971400915609348. View

Waelchli R, Aylett S, Atherton D, Thompson D, Chong W, Kinsler V . Classification of neurological abnormalities in children with congenital melanocytic naevus syndrome identifies magnetic resonance imaging as the best predictor of clinical outcome. Br J Dermatol. 2015; 173(3):739-50. PMC: 4737261. DOI: 10.1111/bjd.13898. View

Ramaswamy V, Delaney H, Haque S, Marghoob A, Khakoo Y . Spectrum of central nervous system abnormalities in neurocutaneous melanocytosis. Dev Med Child Neurol. 2012; 54(6):563-8. DOI: 10.1111/j.1469-8749.2012.04275.x. View

Polubothu S, McGuire N, Al-Olabi L, Baird W, Bulstrode N, Chalker J . Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi. Br J Dermatol. 2019; 182(2):434-443. PMC: 7028140. DOI: 10.1111/bjd.18106. View

Clarke J, Perez H, Jacks L, Panageas K, DeAngelis L . Leptomeningeal metastases in the MRI era. Neurology. 2010; 74(18):1449-54. PMC: 2871005. DOI: 10.1212/WNL.0b013e3181dc1a69. View

Sharouf F, Zaben M, Lammie A, Leach P, Bhatti M . Neurocutaneous melanosis presenting with hydrocephalus and malignant transformation: case-based update. Childs Nerv Syst. 2018; 34(8):1471-1477. PMC: 6060827. DOI: 10.1007/s00381-018-3851-5. View

Lang E, Kasprowicz M, Smielewski P, Pickard J, Czosnyka M . Changes in Cerebral Partial Oxygen Pressure and Cerebrovascular Reactivity During Intracranial Pressure Plateau Waves. Neurocrit Care. 2014; 23(1):85-91. DOI: 10.1007/s12028-014-0074-9. View

Jakchairoongruang K, Khakoo Y, Beckwith M, Barkovich A . New insights into neurocutaneous melanosis. Pediatr Radiol. 2018; 48(12):1786-1796. PMC: 7469866. DOI: 10.1007/s00247-018-4205-x. View

Kim H, Park J, Gwak H, Kwon J, Shin S, Yoo H . Clinical outcome of cerebrospinal fluid shunts in patients with leptomeningeal carcinomatosis. World J Surg Oncol. 2019; 17(1):59. PMC: 6438037. DOI: 10.1186/s12957-019-1595-7. View

10.

Hale E, Stein J, Ben-Porat L, Panageas K, Eichenbaum M, Marghoob A . Association of melanoma and neurocutaneous melanocytosis with large congenital melanocytic naevi--results from the NYU-LCMN registry. Br J Dermatol. 2005; 152(3):512-7. DOI: 10.1111/j.1365-2133.2005.06316.x. View

11.

Humes R, Roskamp J, Eisenbrey A . Melanosis and hydrocephalus. Report of four cases. J Neurosurg. 1984; 61(2):365-8. DOI: 10.3171/jns.1984.61.2.0365. View

12.

Kinsler V, Aylett S, Coley S, Chong W, Atherton D . Central nervous system imaging and congenital melanocytic naevi. Arch Dis Child. 2001; 84(2):152-5. PMC: 1718635. DOI: 10.1136/adc.84.2.152. View

13.

Nigim F, Critchlow J, Kasper E . Role of ventriculoperitoneal shunting in patients with neoplasms of the central nervous system: An analysis of 59 cases. Mol Clin Oncol. 2016; 3(6):1381-1386. PMC: 4665378. DOI: 10.3892/mco.2015.627. View

14.

Berger M, Baumeister B, Geyer J, MILSTEIN J, Kanev P, Leroux P . The risks of metastases from shunting in children with primary central nervous system tumors. J Neurosurg. 1991; 74(6):872-7. DOI: 10.3171/jns.1991.74.6.0872. View

15.

Krengel S, Scope A, Dusza S, Vonthein R, Marghoob A . New recommendations for the categorization of cutaneous features of congenital melanocytic nevi. J Am Acad Dermatol. 2012; 68(3):441-51. DOI: 10.1016/j.jaad.2012.05.043. View

16.

Kadonaga J, Frieden I . Neurocutaneous melanosis: definition and review of the literature. J Am Acad Dermatol. 1991; 24(5 Pt 1):747-55. DOI: 10.1016/0190-9622(91)70115-i. View

17.

Mitre V, Heym K, Clark G, Venkatramani R . Neurocutaneous Melanocytosis and Leptomeningeal Melanoma. J Pediatr Hematol Oncol. 2019; 43(2):e195-e197. DOI: 10.1097/MPH.0000000000001680. View

18.

Larkin J, Chiarion-Sileni V, Gonzalez R, Grob J, Rutkowski P, Lao C . Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma. N Engl J Med. 2019; 381(16):1535-1546. DOI: 10.1056/NEJMoa1910836. View

19.

Gold C, Odom N, Srinivasan S, Schaff L, Haggiagi A, Odia Y . Electrographic Correlates of Plateau Waves in Patients With Leptomeningeal Metastases. Neurohospitalist. 2016; 6(4):161-166. PMC: 5029554. DOI: 10.1177/1941874416648194. View

20.

Schaff L, Marghoob A, Rosenblum M, Meyer R, Khakoo Y . Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression. Pediatr Dermatol. 2019; 36(4):497-500. PMC: 6620153. DOI: 10.1111/pde.13804. View