Inverse Association Between Body Mass Index and All-cause Mortality in Rural Chinese Adults: 15-year Follow-up of the Anqing Cohort Study

Overview

Journal BMJ Open

Specialty General Medicine

Date 2021 Aug 31

PMID 34462277

Authors

Jie Yang

Nannan Cheng

Yue Zhang

Lijing Ye

Jingyi Li

Ziyi Zhou

Zhuo Wang

Lishun Liu

Xiao Huang

Xinglong Liang

Tianchi Ling

Yongcheng Xu

Yun Song

Binyan Wang

Genfu Tang

Xianhui Qin

Pierre Zalloua

Huisheng Zhang

Fangrong Yan

Xiping Xu

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the association between body mass index (BMI) and all-cause mortality in a Chinese rural population.

Design: Prospective cohort study.

Setting: This study was conducted from 2003 to 2018 in Anqing, Anhui Province, China.

Participants: 17 851 participants aged 25-64 years (49.4% female) attending physical examinations and questionnaire were included in this study. The inclusion criterion was families having a minimum of three participating siblings. The exclusion criteria included participants without family number and BMI data at baseline.

Outcome Measures: The outcome measure was all-cause mortality. Generalized estimating equation (GEE) regression analysis was performed to determine the association between baseline BMI and all-cause mortality.

Results: During a mean follow-up period of 14.1 years, 730 deaths (8.0%) occurred among men, and 321 deaths (3.6%) occurred among women. The mean BMI for males was 21.3[Formula: see text] kg/m, and for female it was 22.1±3.1 kg/m. Baseline BMI was significantly inversely associated with all-cause mortality risk for per SD increase (OR, 0.79 (95% CI, 0.72 to 0.87) for males; OR, 0.88 (95% CI, 0.76 to 1.01) for females). When BMI was stratified with cut points at 20 and 24 kg/m, compared with the low BMI group, a significantly lower risk of death was found in the high BMI group (BMI ≥24: OR, 0.57 (95% CI, 0.43 to 0.77) in males; 0.65 (95% CI, 0.46 to 0.93) in females) after adjustment for relevant factors.

Conclusions: In this relatively lean rural Chinese population, the risk of all-cause mortality decreased with increasing BMI. The excess risk of all-cause mortality associated with a high BMI was not seen among this rural population.

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