Potential Biomarkers and Targets of Mitochondrial Dynamics

Overview

Journal Clin Transl Med

Publisher Wiley

Specialty General Medicine

Date 2021 Aug 30

PMID 34459143

Citations 15

Authors

Liyang Li

Ruixue Qi

Linlin Zhang

Yuexin Yu

Jiayun Hou

Yutong Gu

Dongli Song

Xiangdong Wang

Affiliations

Soon will be listed here.

Abstract

Mitochondrial dysfunction contributes to the imbalance of cellular homeostasis and the development of diseases, which is regulated by mitochondria-associated factors. The present review aims to explore the process of the mitochondrial quality control system as a new source of the potential diagnostic biomarkers and/or therapeutic targets for diseases, including mitophagy, mitochondrial dynamics, interactions between mitochondria and other organelles (lipid droplets, endoplasmic reticulum, endosomes, and lysosomes), as well as the regulation and posttranscriptional modifications of mitochondrial DNA/RNA (mtDNA/mtRNA). The direct and indirect influencing factors were especially illustrated in understanding the interactions among regulators of mitochondrial dynamics. In addition, mtDNA/mtRNAs and proteomic profiles of mitochondria in various lung diseases were also discussed as an example. Thus, alternations of mitochondria-associated regulators can be a new category of biomarkers and targets for disease diagnosis and therapy.

Citing Articles

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