Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers

Overview

Journal Front Pharmacol

Date 2021 Aug 30

PMID 34456716

Citations 13

Authors

Amirhossein Davoodvandi

Marjan Farshadi

Noushid Zare

Seyed Amirreza Akhlagh

Esmail Alipour Nosrani

Maryam Mahjoubin-Tehran

Parisa Kangari

Seyedeh Maryam Sharafi

Haroon Khan

Michael Aschner

Ghazaleh Baniebrahimi

Hamed Mirzaei

Affiliations

Soon will be listed here.

Abstract

Gastrointestinal (GI) cancers are known as frequently occurred solid malignant tumors that can cause the high rate mortality in the world. Metastasis is a significant destructive feature of tumoral cells, which directly correlates with decreased prognosis and survival. Curcumin, which is found in turmeric, has been identified as a potent therapeutic natural bioactive compound (Curcuma longa). It has been traditionally applied for centuries to treat different diseases, and it has shown efficacy for its anticancer properties. Numerous studies have revealed that curcumin inhibits migration and metastasis of GI cancer cells by modulating various genes and proteins, i.e., growth factors, inflammatory cytokines and their receptors, different types of enzymes, caspases, cell adhesion molecules, and cell cycle proteins. Herein, we summarized the antimetastatic effects of curcumin in GI cancers, including pancreatic cancer, gastric cancer, colorectal cancer, oral cancer, and esophageal cancer.

Citing Articles

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The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management.

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Current status of Complementary and Alternative Medicine Interventions in the Management of Pancreatic Cancer - An Overview.

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