Genomic Epidemiology and Evolution of Duck Hepatitis A Virus

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Aug 28

PMID 34452457

Citations 3

Authors

Eniko Feher

Szilvia Jakab

Krisztina Bali

Eszter Kaszab

Borbala Nagy

Katalin Ihasz

Adam Balint

Vilmos Palya

Krisztian Banyai

Affiliations

Soon will be listed here.

Abstract

Duck hepatitis A virus (DHAV), an avian picornavirus, causes high-mortality acute disease in ducklings. Among the three serotypes, DHAV-1 is globally distributed, whereas DHAV-2 and DHAV-3 serotypes are chiefly restricted to Southeast Asia. In this study, we analyzed the genomic evolution of DHAV-1 strains using extant GenBank records and genomic sequences of 10 DHAV-1 strains originating from a large disease outbreak in 2004-2005, in Hungary. Recombination analysis revealed intragenotype recombination within DHAV-1 as well as intergenotype recombination events involving DHAV-1 and DHAV-3 strains. The intergenotype recombination occurred in the VP0 region. Diversifying selection seems to act at sites of certain genomic regions. Calculations estimated slightly lower rates of evolution of DHAV-1 (mean rates for individual protein coding regions, 5.6286 × 10 to 1.1147 × 10 substitutions per site per year) compared to other picornaviruses. The observed evolutionary mechanisms indicate that whole-genome-based analysis of DHAV strains is needed to better understand the emergence of novel strains and their geographical dispersal.

Citing Articles

The Development of a One-Step PCR Assay for Rapid Detection of an Attenuated Vaccine Strain of Duck Hepatitis Virus Type 3 in Korea.

Yu C, Park J, Kim S, Choi Y, Cha S, Jang H Vet Sci. 2025; 12(1).

PMID: 39852883 PMC: 11768531. DOI: 10.3390/vetsci12010008.

Identification and characterization of multiple novel viruses in fecal samples of cormorants.

Ji L, Zhao R, Pei Y, Sun Y, Sun X, Ji L Front Vet Sci. 2025; 11():1528233.

PMID: 39850588 PMC: 11755888. DOI: 10.3389/fvets.2024.1528233.

The Impact of Genetic Variation on Duck Hepatitis A Virus (DHAV) Vaccine Efficacy: A Comparative Study of DHAV-1 and DHAV-3 Against Emerging Variant Strains.

Kim S, Yu C, Park J, Ma X, Zhu T, Li Y Vaccines (Basel). 2025; 12(12.

PMID: 39772077 PMC: 11680345. DOI: 10.3390/vaccines12121416.

One-Step Multiplex Real-Time Fluorescent Quantitative Reverse Transcription PCR for Simultaneous Detection of Four Waterfowl Viruses.

Wang C, Liu H, Cheng J, Pan S, Yang W, Wei X Microorganisms. 2025; 12(12.

PMID: 39770626 PMC: 11679685. DOI: 10.3390/microorganisms12122423.

Codon Usage Analysis Reveals Distinct Evolutionary Patterns and Host Adaptation Strategies in Duck Hepatitis Virus 1 (DHV-1) Phylogroups.

Zhao Y, Su X, He D Viruses. 2024; 16(9).

PMID: 39339856 PMC: 11437458. DOI: 10.3390/v16091380.

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