Serological Evidence of Phleboviruses in Domestic Animals on the Pre-Apennine Hills (Northern Italy)

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Aug 28

PMID 34452442

Citations 6

Authors

Davide Lelli

Vittorio Scanferla

Ana Moreno

Enrica Sozzi

Valentina Ravaioli

Maria Renzi

Giovanni Tosi

Michele Dottori

Antonio Lavazza

Mattia Calzolari

Affiliations

Soon will be listed here.

Abstract

Phleboviruses are arboviruses transmitted by sand flies, mosquitoes and ticks. Some sand fly-borne phleboviruses cause illnesses in humans, such as the summer fevers caused by the Sicilian and Naples viruses or meningitis caused by the Toscana virus. Indeed, traces of several phleboviral infections have been serologically detected in domestic animals, but their potential pathogenic role in vertebrates other than humans is still unclear, as is the role of vertebrates as potential reservoirs of these viruses. In this study, we report the results of a serological survey performed on domestic animals sampled in Northern Italy, against four phleboviruses isolated from sand flies in the same area. The sera of 23 dogs, 165 sheep and 23 goats were tested with a virus neutralization assay for Toscana virus, Fermo virus, Ponticelli I virus and Ponticelli III virus. Neutralizing antibodies against one or more phleboviruses were detected in four out of 23 dogs, 31 out of 165 sheep and 12 out of 23 goats. This study shows preliminary evidence for the distribution pattern of phleboviral infections in different animal species, highlighting the potential infection of the Toscana virus in dogs and the Fermo virus in goats.

Citing Articles

Epidemiology of Sandfly-Borne Phleboviruses in North Africa: An Overview.

Sellali S, Lafri I, Garni R, Manseur H, Besbaci M, Lafri M Insects. 2024; 15(11).

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Toscana Virus in Wild-Caught Sand Flies in Portugal, Findings from the National Vector Surveillance Network, 2023.

Amaro F, Ze-Ze L, Osorio H, Soares P, Silva M, Freitas I Pathogens. 2024; 13(10).

PMID: 39452776 PMC: 11510618. DOI: 10.3390/pathogens13100905.

Development of a Real-Time PCR Assay for the Detection of the Phlebovirus Fermo Virus.

Calzolari M, Russo S, Marzani K, Dalmonte G, Ricchi M, Bonilauri P Viruses. 2023; 15(10).

PMID: 37896859 PMC: 10612048. DOI: 10.3390/v15102082.

Seroprevalence of Toscana and sandfly fever Sicilian viruses in humans and livestock animals from western Saudi Arabia.

Al-Numaani S, Al-Nemari A, El-Kafrawy S, Hassan A, Tolah A, Alghanmi M One Health. 2023; 17:100601.

PMID: 37520847 PMC: 10372353. DOI: 10.1016/j.onehlt.2023.100601.

New Isolation of Ponticelli III Virus (: ) in Emilia-Romagna Region, Italy.

Daoudi M, Romeo G, Marzani K, Petrella A, Bonilauri P, Lelli D Viruses. 2023; 15(2).

PMID: 36851636 PMC: 9964127. DOI: 10.3390/v15020422.

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