Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Aug 28

PMID 34452435

Citations 2

Authors

Reed F Johnson

Lauren A Keith

Timothy K Cooper

Srikanth Yellayi

Nicole M Josleyn

Krisztina B Janosko

James D Pettitt

David Thomasson

Katie R Hagen

Robin Gross

John G Bernbaum

Debbie Douglas

Jeffrey Solomon

Mark Martinez

Kurt Cooper

Marisa St Claire

Danny R Ragland

Peter B Jahrling

Jens H Kuhn

Andrew E Arai

Affiliations

Soon will be listed here.

Abstract

Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial hemorrhages. Previous experiments have demonstrated that intravenous (IV) cowpox virus (CPXV) exposure of macaques mimics human hemorrhagic smallpox. The goal of this experiment was to further understand the onset, nature, and severity of cardiac pathology and how it may contribute to disease. The findings support an acute late-stage myocarditis with lymphohistiocytic infiltrates in the CPXV model of hemorrhagic smallpox.

Citing Articles

Cardiac Involvement in Monkeypox Outbreak.

Manan M, Nawaz I, Zafar F, Manan H, Nawaz Y Discoveries (Craiova). 2023; 11(3):e171.

PMID: 37753488 PMC: 10518651. DOI: 10.15190/d.2023.10.

Myocarditis Attributable to Monkeypox Virus Infection in 2 Patients, United States, 2022.

Rodriguez-Nava G, Kadlecik P, Filardo T, Ain D, Cooper J, McCormick D Emerg Infect Dis. 2022; 28(12):2508-2512.

PMID: 36179413 PMC: 9707588. DOI: 10.3201/eid2812.221276.

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