Zebrafish Model in Ophthalmology to Study Disease Mechanism and Drug Discovery

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2021 Aug 28

PMID 34451814

Citations 14

Authors

Yiwen Hong

Yan Luo

Affiliations

Soon will be listed here.

Abstract

Visual impairment and blindness are common and seriously affect people's work and quality of life in the world. Therefore, the effective therapies for eye diseases are of high priority. Zebrafish () is an alternative vertebrate model as a useful tool for the mechanism elucidation and drug discovery of various eye disorders, such as cataracts, glaucoma, diabetic retinopathy, age-related macular degeneration, photoreceptor degeneration, etc. The genetic and embryonic accessibility of zebrafish in combination with a behavioral assessment of visual function has made it a very popular model in ophthalmology. Zebrafish has also been widely used in ocular drug discovery, such as the screening of new anti-angiogenic compounds or neuroprotective drugs, and the oculotoxicity test. In this review, we summarized the applications of zebrafish as the models of eye disorders to study disease mechanism and investigate novel drug treatments.

Citing Articles

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