Anti-Inflammatory Effects of Callus Extract Via Suppression of MAPK and NF-κB Signaling

Overview

Journal Plants (Basel)

Date 2021 Aug 28

PMID 34451680

Citations 2

Authors

Hyeon-Ji Lim

Eun Yee Jie

In-Sun Park

Sang-Jun Kim

Woo Seok Ahn

Seung-Il Jeong

Suk Weon Kim

Chan-Hun Jung

Affiliations

Soon will be listed here.

Abstract

is used in folk medicine to treat pain and allergic syndromes in Korea. However, the antibacterial and anti-inflammatory activities of callus extract remain unexplored. In this study, we aimed to evaluate the callus of pharmacological activity. Therefore, we first established in vitro calluses of via plant tissue culture methods. We then evaluated the antioxidant and anti-inflammatory effects of callus extract in lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells. The callus extract showed antioxidant and anti-inflammatory effects. These effects were regulated via suppression of mitogen-activated protein kinase signaling through LPS-induced translocation of nuclear factor kappa B (NF-κB) p65 from the cytoplasm to the nucleus. callus extract also showed antibacterial and anti-inflammatory activities in -treated HaCaT keratinocyte cells. These results indicate that callus extract has antioxidant, antibacterial and anti-inflammatory activities, suggesting its possible application in the treatment of inflammatory disorders.

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