First Report of a Case of Ocular Infection Caused by in Poland

Overview

Journal Pathogens

Date 2021 Aug 28

PMID 34451510

Citations 2

Authors

Robert Kuthan

Anna K Kurowska

Justyna Izdebska

Jacek P Szaflik

Anna Lutynska

Ewa Swoboda-Kopec

Affiliations

Soon will be listed here.

Abstract

This report describes the first case of an ocular infection induced by in Poland. The patient was a 51-year-old immunocompetent contact lens user who suffered from subacute keratitis and progressive granulomatous uveitis. He underwent penetrating keratoplasty for corneal perforation, followed by cataract surgery due to rapid uveitic cataract. A few weeks later, intraocular lens removal and pars plana vitrectomy were necessary due to endophthalmitis. The patient was treated with topical, systemic, and intravitreal voriconazole with improvement; however, the visual outcome was poor. The pathogen was identified by MALDI-TOF MS.

Citing Articles

Deep cutaneous fungal infection in an immunocompetent individual caused by a biological pesticide: a rare case report.

Zheng C, Li W, Gao Z, Yu Q, Yang L BMC Infect Dis. 2025; 25(1):341.

PMID: 40069617 PMC: 11895385. DOI: 10.1186/s12879-025-10707-x.

Synthesis and crystal structure of piperidinyl propanenitrile towards the preparation of piperidine based bioactive films for drug delivery applications.

Mohamed-Ezzat R, Hasanin M, Kariuki B, Dacrory S Sci Rep. 2025; 15(1):705.

PMID: 39753604 PMC: 11698915. DOI: 10.1038/s41598-024-81996-6.

Treatment of resistant Paecilomyces lilacinus keratitis with topical voriconazole and oral itraconazole: a rare case report from Somalia.

Mohamed H, Hassan I, Yussuf A, Nor Y, Ahmed A, Roble A Ann Med Surg (Lond). 2024; 86(4):2172-2175.

PMID: 38576982 PMC: 10990336. DOI: 10.1097/MS9.0000000000001925.

References

Szymanek-Majchrzak K, Mlynarczyk A, Kuthan R, Sawicka-Grzelak A, Majchrzak K, Kawecki D . Significance of Screening Tests and the Incidence of New Delhi Metallo-beta-lactamase-Producing Gram-negative Bacilli in the Surgery and Transplantation Wards of a Warsaw Medical Center During the Period From April 2014 to May 2017. Transplant Proc. 2018; 50(7):2159-2163. DOI: 10.1016/j.transproceed.2018.04.002. View

Todokoro D, Hosogai M, Nakano S, Akiyama H . Effective diagnosis by real-time PCR of herpes simplex diffuse endotheliitis that is similar in appearance to fungal keratitis: case series. J Ophthalmic Inflamm Infect. 2021; 11(1):20. PMC: 8273046. DOI: 10.1186/s12348-021-00250-6. View

Moreira D, Oliveira M, Borba C . Human Pathogenic from Food. Microorganisms. 2018; 6(3). PMC: 6164242. DOI: 10.3390/microorganisms6030064. View

Rychert J, Slechta E, Barker A, Miranda E, Babady N, Tang Y . Multicenter Evaluation of the Vitek MS v3.0 System for the Identification of Filamentous Fungi. J Clin Microbiol. 2017; 56(2). PMC: 5786734. DOI: 10.1128/JCM.01353-17. View

Calvillo-Medina R, Ponce-Angulo D, Raymundo T, Muller-Morales C, Escudero-Leyva E, Guillen J . Purpureocillium roseum sp. nov. A new ocular pathogen for humans and mice resistant to antifungals. Mycoses. 2020; 64(2):162-173. DOI: 10.1111/myc.13198. View

Martinez E, Vandergriff T, Vasquez R . Cutaneous infection in an immunocompromised patient in the setting of postthrombotic syndrome successfully treated with posaconazole. JAAD Case Rep. 2020; 6(11):1144-1146. PMC: 7591334. DOI: 10.1016/j.jdcr.2020.07.001. View

Gajjar D, Pal A, Ghodadra B, Vasavada A . Microscopic evaluation, molecular identification, antifungal susceptibility, and clinical outcomes in fusarium, Aspergillus and, dematiaceous keratitis. Biomed Res Int. 2013; 2013:605308. PMC: 3821891. DOI: 10.1155/2013/605308. View

Ting D, Ho C, Deshmukh R, Said D, Dua H . Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance. Eye (Lond). 2021; 35(4):1084-1101. PMC: 8102486. DOI: 10.1038/s41433-020-01339-3. View

Mahmoudi S, Masoomi A, Ahmadikia K, Tabatabaei S, Soleimani M, Rezaie S . Fungal keratitis: An overview of clinical and laboratory aspects. Mycoses. 2018; 61(12):916-930. DOI: 10.1111/myc.12822. View

10.

Chew R, Dorman A, Woods M . Purpureocillium lilacinum keratitis: a case series and review of the literature. Can J Ophthalmol. 2016; 51(5):382-385. DOI: 10.1016/j.jcjo.2016.05.013. View

11.

Oliveira M, Carmo A, Rosa A, Murta J . Posaconazole in the treatment of refractory (former ) keratitis: the salvation when nothing works. BMJ Case Rep. 2019; 12(4). PMC: 6505977. DOI: 10.1136/bcr-2018-228645. View

12.

Tangmonkongvoragul C, Chokesuwattanaskul S, Tananuvat N, Pongpom M, Upaphong P, Saysithidej S . The Clinical Features and Prognostic Factors for Treatment Outcomes of Dematiaceous Fungal Keratitis over 9 Years at a Tertiary Eye Care in Northern Thailand. J Fungi (Basel). 2021; 7(7). PMC: 8303605. DOI: 10.3390/jof7070526. View

13.

Yildiz E, Ailani H, Hammersmith K, Eagle Jr R, Rapuano C, Cohen E . Alternaria and paecilomyces keratitis associated with soft contact lens wear. Cornea. 2010; 29(5):564-8. DOI: 10.1097/ICO.0b013e3181ba0cde. View

14.

Chen Y, Yeh L, Ma D, Lin H, Sun C, Tan H . Paecilomyces/Purpureocillium keratitis: A consecutive study with a case series and literature review. Med Mycol. 2019; 58(3):293-299. DOI: 10.1093/mmy/myz059. View

15.

Bader O . Fungal Species Identification by MALDI-ToF Mass Spectrometry. Methods Mol Biol. 2016; 1508:323-337. DOI: 10.1007/978-1-4939-6515-1_19. View

16.

Torres-Sangiao E, Rodriguez C, Garcia-Riestra C . Application and Perspectives of MALDI-TOF Mass Spectrometry in Clinical Microbiology Laboratories. Microorganisms. 2021; 9(7). PMC: 8307939. DOI: 10.3390/microorganisms9071539. View

17.

Tarka P, Borowska-Solonynko A, Brzozowska M, Nitsch-Osuch A, Kanecki K, Kuthan R . No-Touch Automated Room Disinfection after Autopsies of Exhumed Corpses. Pathogens. 2020; 9(8). PMC: 7460184. DOI: 10.3390/pathogens9080648. View

18.

Perdomo H, Cano J, Gene J, Garcia D, Hernandez M, Guarro J . Polyphasic analysis of Purpureocillium lilacinum isolates from different origins and proposal of the new species Purpureocillium lavendulum. Mycologia. 2012; 105(1):151-61. DOI: 10.3852/11-190. View

19.

Kierzkowska M, Majewska A, Kuthan R, Sawicka-Grzelak A, Mlynarczyk G . A comparison of Api 20A vs MALDI-TOF MS for routine identification of clinically significant anaerobic bacterial strains to the species level. J Microbiol Methods. 2012; 92(2):209-12. DOI: 10.1016/j.mimet.2012.12.007. View

20.

Xuguang S, Zhixin W, Zhiqun W, Shiyun L, Ran L . Ocular fungal isolates and antifungal susceptibility in northern China. Am J Ophthalmol. 2006; 143(1):131-133. DOI: 10.1016/j.ajo.2006.09.042. View