Tissue Distribution of Stem Cell Factor in Adults

Overview

Journal Exp Mol Pathol

Publisher Elsevier

Specialties Molecular Biology
Pathology

Date 2021 Aug 27

PMID 34450114

Citations 5

Authors

Brittni M Foster

Kendall L Langsten

Ammar Mansour

Lihong Shi

Bethany A Kerr

Affiliations

Soon will be listed here.

Abstract

Stem cell factor (SCF) is an essential cytokine during development and is necessary for gametogenesis, hematopoiesis, mast cell development, stem cell function, and melanogenesis. Here, we measure SCF concentration and distribution in adult humans and mice using gene expression analysis, tissue staining, and organ protein lysates. We demonstrate continued SCF expression in many cell types and tissues into adulthood. Tissues with high expression in adult humans included stomach, spleen, kidney, lung, and pancreas. In mice, we found high SCF expression in the esophagus, ovary, uterus, kidney, and small intestine. Future studies may correlate our findings of increased, organ-specific SCF concentrations within adult tissues with increased risk of SCF/CD117-related disease.

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