A Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention Program Is Associated with Increased Leukocyte Telomere Length in Children and Adolescents with Overweight and Obesity

Overview

Journal Nutrients

Date 2021 Aug 27

PMID 34444842

Citations 11

Authors

George Paltoglou

Christina Raftopoulou

Nicolas C Nicolaides

Sofia M Genitsaridi

Sofia I Karampatsou

Marina Papadopoulou

Penio Kassari

Evangelia Charmandari

Affiliations

Soon will be listed here.

Abstract

Leucocyte telomere length (LTL) is a robust marker of biological aging and is associated with obesity and cardiometabolic risk factors in childhood and adolescence. We investigated the effect of a structured, comprehensive, multidisciplinary, personalized, lifestyle intervention program of healthy diet and physical exercise on LTL in 508 children and adolescents (239 males, 269 females; 282 prepubertal, 226 pubertal), aged 10.14 ± 0.13 years. Participants were classified as obese ( = 267, 52.6%), overweight ( = 174, 34.2%), or of normal BMI ( = 67, 13.2%) according to the International Obesity Task Force (IOTF) cutoff points and were studied prospectively for one year. We demonstrated that LTL increased significantly after 1 year of the lifestyle interventions, irrespective of gender, pubertal status, or body mass index (BMI). Waist circumference was the best negative predictor of LTL at initial assessment. The implementation of the lifestyle interventions also resulted in a significant improvement in clinical (BMI, BMI z-score and waist to height ratio) and body composition indices of obesity, inflammatory markers, hepatic enzymes, glycated hemoglobin (HbA1C), quantitative insulin sensitivity check index (QUICKI), and lipid profile in all participants. These findings indicate that the increased LTL may be associated with a more favorable metabolic profile and decreased morbidity later in life.

Citing Articles

Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?.

Munoz-Pardeza J, Lopez-Gil J, Huerta-Uribe N, Hormazabal-Aguayo I, Ojeda-Rodriguez A, Marti Del Moral A Pediatr Res. 2024; .

PMID: 39543404 DOI: 10.1038/s41390-024-03732-0.

Improvement in Symptoms of Depression and Anxiety and Cardiometabolic Risk Factors in Children and Adolescents with Overweight and Obesity Following the Implementation of a Multidisciplinary Personalized Lifestyle Intervention Program.

Vourdoumpa A, Paltoglou G, Manou M, Mantzou E, Kassari P, Papadopoulou M Nutrients. 2024; 16(21).

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The association of telomere length with body mass index and immunological factors differs according to physical activity practice among children and adolescents.

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The Role of Secreted Frizzled-Related Protein 5 (Sfrp5) in Overweight and Obesity in Childhood and Adolescence.

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The Impact of Thyroid Hormones on Cardiometabolic Risk in Children and Adolescents with Obesity, Overweight and Normal Body Mass Index (BMI): A One-Year Intervention Study.

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