Trends and Patterns of Knee Osteoarthritis in China: A Longitudinal Study of 17.7 Million Adults from 2008 to 2017

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2021 Aug 27

PMID 34444613

Citations 26

Authors

Hongbo Chen

Junhui Wu

Zijing Wang

Yao Wu

Tao Wu

Yiqun Wu

Mengying Wang

Siyue Wang

Xiaowen Wang

Jiating Wang

Huan Yu

Yonghua Hu

Shaomei Shang

Affiliations

Soon will be listed here.

Abstract

Knee osteoarthritis (KOA) provides many challenges on the healthcare system. However, few studies have reported the epidemiology, particularly in a large population. Our study aimed to estimate the prevalence, incidence, trends, and patterns of diagnosed KOA in China. This was a longitudinal study. We used health insurance claims of 17.7 million adults from 2008-2017 to identify people with KOA. Trends in prevalence and incidence were analyzed using joinpoint regression. We identified 2,447,990 people with KOA in Beijing, 60% of which were women. The 10-year average age-standardized prevalence and incidence of KOA was, respectively, 4.6% and 25.2 per 1000 person-years. Prevalence increased with age, surging after 55 years old. The average crude prevalence was 13.2% for people over 55 years old. The prevalence showed an increasing trend from 2008 to 2017, including a period of rapid rise from 2008 to 2011 ( < 0.05); the increase in prevalence was greatest in people under 35 years old ( 0.05). Our analyses showed that the annual prevalence rate of KOA increased significantly from 2008 to 2017 in China. We need to increase our attention to women and the elderly over 55 years old, and also be alert to the younger trend of incidence of KOA.

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References

McAlindon T, Bannuru R, Sullivan M, Arden N, Berenbaum F, Bierma-Zeinstra S . OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014; 22(3):363-88. DOI: 10.1016/j.joca.2014.01.003. View

Cho H, Morey V, Kang J, Kim K, Kim T . Prevalence and Risk Factors of Spine, Shoulder, Hand, Hip, and Knee Osteoarthritis in Community-dwelling Koreans Older Than Age 65 Years. Clin Orthop Relat Res. 2015; 473(10):3307-14. PMC: 4562942. DOI: 10.1007/s11999-015-4450-3. View

Deshpande B, Katz J, Solomon D, Yelin E, Hunter D, Messier S . Number of Persons With Symptomatic Knee Osteoarthritis in the US: Impact of Race and Ethnicity, Age, Sex, and Obesity. Arthritis Care Res (Hoboken). 2016; 68(12):1743-1750. PMC: 5319385. DOI: 10.1002/acr.22897. View

Blagojevic M, Jinks C, Jeffery A, Jordan K . Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2009; 18(1):24-33. DOI: 10.1016/j.joca.2009.08.010. View

Mikesky A, Mazzuca S, Brandt K, Perkins S, Damush T, Lane K . Effects of strength training on the incidence and progression of knee osteoarthritis. Arthritis Rheum. 2006; 55(5):690-9. DOI: 10.1002/art.22245. View

Prieto-Alhambra D, Judge A, Javaid M, Cooper C, Diez-Perez A, Arden N . Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2013; 73(9):1659-64. PMC: 3875433. DOI: 10.1136/annrheumdis-2013-203355. View

Zghebi S, Steinke D, Carr M, Rutter M, Emsley R, Ashcroft D . Examining trends in type 2 diabetes incidence, prevalence and mortality in the UK between 2004 and 2014. Diabetes Obes Metab. 2017; 19(11):1537-1545. DOI: 10.1111/dom.12964. View

Tang X, Wang S, Zhan S, Niu J, Tao K, Zhang Y . The Prevalence of Symptomatic Knee Osteoarthritis in China: Results From the China Health and Retirement Longitudinal Study. Arthritis Rheumatol. 2015; 68(3):648-53. DOI: 10.1002/art.39465. View

Laxafoss E, Jacobsen S, Gosvig K, Sonne-Holm S . Case definitions of knee osteoarthritis in 4,151 unselected subjects: relevance for epidemiological studies: the Copenhagen Osteoarthritis Study. Skeletal Radiol. 2010; 39(9):859-66. DOI: 10.1007/s00256-009-0856-x. View

10.

Nguyen U, Zhang Y, Zhu Y, Niu J, Zhang B, Felson D . Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data. Ann Intern Med. 2011; 155(11):725-32. PMC: 3408027. DOI: 10.7326/0003-4819-155-11-201112060-00004. View

11.

Andersson C, Vasan R . Epidemiology of cardiovascular disease in young individuals. Nat Rev Cardiol. 2017; 15(4):230-240. DOI: 10.1038/nrcardio.2017.154. View

12.

Felson D, Zhang Y, Hannan M, Naimark A, Weissman B, Aliabadi P . Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum. 1997; 40(4):728-33. DOI: 10.1002/art.1780400420. View

13.

Pal C, Singh P, Chaturvedi S, Pruthi K, Vij A . Epidemiology of knee osteoarthritis in India and related factors. Indian J Orthop. 2016; 50(5):518-522. PMC: 5017174. DOI: 10.4103/0019-5413.189608. View

14.

Zang C, Zeng Q, Li X, Dong H, Zhang A, Zhao Q . [A cross-sectional population survey of knee osteoarthritis in Taiyuan region]. Zhonghua Nei Ke Za Zhi. 2006; 45(7):533-6. View

15.

Sun X, Zhen X, Hu X, Li Y, Gu S, Gu Y . Osteoarthritis in the Middle-Aged and Elderly in China: Prevalence and Influencing Factors. Int J Environ Res Public Health. 2019; 16(23). PMC: 6926632. DOI: 10.3390/ijerph16234701. View

16.

Kulkarni K, Karssiens T, Kumar V, Pandit H . Obesity and osteoarthritis. Maturitas. 2016; 89:22-8. DOI: 10.1016/j.maturitas.2016.04.006. View

17.

Jiang L, Rong J, Zhang Q, Hu F, Zhang S, Li X . Prevalence and associated factors of knee osteoarthritis in a community-based population in Heilongjiang, Northeast China. Rheumatol Int. 2011; 32(5):1189-95. DOI: 10.1007/s00296-010-1773-y. View

18.

Leyland K, Hart D, Javaid M, Judge A, Kiran A, Soni A . The natural history of radiographic knee osteoarthritis: a fourteen-year population-based cohort study. Arthritis Rheum. 2012; 64(7):2243-51. DOI: 10.1002/art.34415. View

19.

Kim H, Fay M, Feuer E, Midthune D . Permutation tests for joinpoint regression with applications to cancer rates. Stat Med. 2000; 19(3):335-51. DOI: 10.1002/(sici)1097-0258(20000215)19:3<335::aid-sim336>3.0.co;2-z. View

20.

Guillemin F, Rat A, Mazieres B, Pouchot J, Fautrel B, Euller-Ziegler L . Prevalence of symptomatic hip and knee osteoarthritis: a two-phase population-based survey. Osteoarthritis Cartilage. 2011; 19(11):1314-22. DOI: 10.1016/j.joca.2011.08.004. View