Metal-Based Nanomaterials: Work As Drugs and Carriers Against Viral Infections

Overview

Journal Nanomaterials (Basel)

Date 2021 Aug 27

PMID 34443959

Citations 6

Authors

Junlei Yang

Lihuan Yue

Zhu Yang

Yuqing Miao

Ruizhuo Ouyang

Yihong Hu

Affiliations

Soon will be listed here.

Abstract

Virus infection is one of the threats to the health of organisms, and finding suitable antiviral agents is one of the main tasks of current researchers. Metal ions participate in multiple key reaction stages of organisms and maintain the important homeostasis of organisms. The application of synthetic metal-based nanomaterials as an antiviral therapy is a promising new research direction. Based on the application of synthetic metal-based nanomaterials in antiviral therapy, we summarize the research progress of metal-based nanomaterials in recent years. This review analyzes the three inhibition pathways of metal nanomaterials as antiviral therapeutic materials against viral infections, including direct inactivation, inhibition of virus adsorption and entry, and intracellular virus suppression; it further classifies and summarizes them according to their inhibition mechanisms. In addition, the use of metal nanomaterials as antiviral drug carriers and vaccine adjuvants is summarized. The analysis clarifies the antiviral mechanism of metal nanomaterials and broadens the application in the field of antiviral therapy.

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References

Yang Y, Chen Q, Wu J, Kirk T, Xu J, Liu Z . Reduction-Responsive Codelivery System Based on a Metal-Organic Framework for Eliciting Potent Cellular Immune Response. ACS Appl Mater Interfaces. 2018; 10(15):12463-12473. DOI: 10.1021/acsami.8b01680. View

Shionoiri N, Sato T, Fujimori Y, Nakayama T, Nemoto M, Matsunaga T . Investigation of the antiviral properties of copper iodide nanoparticles against feline calicivirus. J Biosci Bioeng. 2012; 113(5):580-6. DOI: 10.1016/j.jbiosc.2011.12.006. View

Ellenberger D, Li B, Smith J, Yi H, Folks T, Robinson H . Optimization of a multi-gene HIV-1 recombinant subtype CRF02_AG DNA vaccine for expression of multiple immunogenic forms. Virology. 2004; 319(1):118-30. DOI: 10.1016/j.virol.2003.10.013. View

Howes P, Chandrawati R, Stevens M . Bionanotechnology. Colloidal nanoparticles as advanced biological sensors. Science. 2014; 346(6205):1247390. DOI: 10.1126/science.1247390. View

Cai W, Chu C, Liu G, Wang Y . Metal-Organic Framework-Based Nanomedicine Platforms for Drug Delivery and Molecular Imaging. Small. 2015; 11(37):4806-22. DOI: 10.1002/smll.201500802. View

Mishra Y, Adelung R, Rohl C, Shukla D, Spors F, Tiwari V . Virostatic potential of micro-nano filopodia-like ZnO structures against herpes simplex virus-1. Antiviral Res. 2011; 92(2):305-12. PMC: 4148000. DOI: 10.1016/j.antiviral.2011.08.017. View

Wang Z, Liu H, Hye Yang S, Wang T, Liu C, Cao Y . Nanoparticle-based artificial RNA silencing machinery for antiviral therapy. Proc Natl Acad Sci U S A. 2012; 109(31):12387-92. PMC: 3412013. DOI: 10.1073/pnas.1207766109. View

Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798):270-273. PMC: 7095418. DOI: 10.1038/s41586-020-2012-7. View

Kolodziejczak-Radzimska A, Jesionowski T . Zinc Oxide-From Synthesis to Application: A Review. Materials (Basel). 2017; 7(4):2833-2881. PMC: 5453364. DOI: 10.3390/ma7042833. View

10.

Vonnemann J, Sieben C, Wolff C, Ludwig K, Bottcher C, Herrmann A . Virus inhibition induced by polyvalent nanoparticles of different sizes. Nanoscale. 2014; 6(4):2353-60. DOI: 10.1039/c3nr04449a. View

11.

Siddiqi K, Rahman A, Tajuddin , Husen A . Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes. Nanoscale Res Lett. 2018; 13(1):141. PMC: 5940970. DOI: 10.1186/s11671-018-2532-3. View

12.

Zhang Z, Zhu X, Hu Y, Liang M, Sun J, Song Y . Five-year antibody persistence in children after one dose of inactivated or live attenuated hepatitis A vaccine. Hum Vaccin Immunother. 2017; 13(6):1-6. PMC: 5489274. DOI: 10.1080/21645515.2016.1278329. View

13.

Kumar R, Nayak M, Sahoo G, Pandey K, Sarkar M, Ansari Y . Iron oxide nanoparticles based antiviral activity of H1N1 influenza A virus. J Infect Chemother. 2019; 25(5):325-329. DOI: 10.1016/j.jiac.2018.12.006. View

14.

Pang C, Zhang P, Mu Y, Ren J, Zhao B . Transformation and Cytotoxicity of Surface-Modified Silver Nanoparticles Undergoing Long-Term Aging. Nanomaterials (Basel). 2020; 10(11). PMC: 7697416. DOI: 10.3390/nano10112255. View

15.

Dungdung R, Bayal M, Valliyott L, Unniyampurath U, Nair S, Pilankatta R . A slow, efficient and safe nanoplatform of tailored ZnS QD-mycophenolic acid conjugates for drug delivery against dengue virus 2 genome replication. Nanoscale Adv. 2022; 2(12):5777-5789. PMC: 9418522. DOI: 10.1039/d0na00725k. View

16.

Zhou Y, Jiang X, Tong T, Fang L, Wu Y, Liang J . High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus. RSC Adv. 2022; 10(24):14161-14169. PMC: 9051606. DOI: 10.1039/d0ra01387k. View

17.

Wang C, Zhu W, Luo Y, Wang B . Gold nanoparticles conjugating recombinant influenza hemagglutinin trimers and flagellin enhanced mucosal cellular immunity. Nanomedicine. 2018; 14(4):1349-1360. PMC: 6177327. DOI: 10.1016/j.nano.2018.03.007. View

18.

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J . Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020; 382(18):1708-1720. PMC: 7092819. DOI: 10.1056/NEJMoa2002032. View

19.

Tong H, Ouyang S, Bi Y, Umezawa N, Oshikiri M, Ye J . Nano-photocatalytic materials: possibilities and challenges. Adv Mater. 2011; 24(2):229-51. DOI: 10.1002/adma.201102752. View

20.

Imai K, Ogawa H, Bui V, Inoue H, Fukuda J, Ohba M . Inactivation of high and low pathogenic avian influenza virus H5 subtypes by copper ions incorporated in zeolite-textile materials. Antiviral Res. 2011; 93(2):225-233. DOI: 10.1016/j.antiviral.2011.11.017. View