The Prognostic Role of Micro-RNAs in Head and Neck Cancers: An Umbrella Review

Overview

Journal J Pers Med

Date 2021 Aug 27

PMID 34442465

Citations 2

Authors

Marco Mariani

Carolina Castagna

Stefania Boccia

Roberta Pastorino

Affiliations

Soon will be listed here.

Abstract

We conducted an umbrella review which synthetizes the findings of systematic reviews available in the literature that investigate the prognostic role of miRNAs as potential biomarkers in the field of tertiary prevention of head and neck Cancer (HNC). We selected systematic reviews in English related to HNC, with meta-analysis of observational studies that reported quantitative prognostic measures, hazard ratios (HRs), overall survival (OS) or disease-free survival (DFS). The methodological quality of the included reviews was assessed by using the AMSTAR-2 tool. The most reported miRNAs were the following: miRNA2, Let7 family and miR17, etc. Four out of six reviews particularly emphasized the link between miRNA21 expression and HNC patients. Recently the cumulative effects of sets of miRNAs have been increasingly studied and might be a stronger predictor of survival than single miRNA.

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