The New Era of Three-Dimensional Histoarchitecture of the Human Endometrium

Overview

Journal J Pers Med

Date 2021 Aug 27

PMID 34442357

Citations 6

Authors

Manako Yamaguchi

Kosuke Yoshihara

Nozomi Yachida

Kazuaki Suda

Ryo Tamura

Tatsuya Ishiguro

Takayuki Enomoto

Affiliations

Soon will be listed here.

Abstract

The histology of the endometrium has traditionally been established by observation of two-dimensional (2D) pathological sections. However, because human endometrial glands exhibit coiling and branching morphology, it is extremely difficult to obtain an entire image of the glands by 2D observation. In recent years, the development of three-dimensional (3D) reconstruction of serial pathological sections by computer and whole-mount imaging technology using tissue clearing methods with high-resolution fluorescence microscopy has enabled us to observe the 3D histoarchitecture of tissues. As a result, 3D imaging has revealed that human endometrial glands form a plexus network in the basalis, similar to the rhizome of grass, whereas mouse uterine glands are single branched tubular glands. This review summarizes the relevant literature on the 3D structure of mouse and human endometrium and discusses the significance of the rhizome structure in the human endometrium and the expected role of understanding the 3D tissue structure in future applications to systems biology.

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