Liquid Biopsy: A Family of Possible Diagnostic Tools

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2021 Aug 27

PMID 34441325

Citations 40

Authors

Battistelli Michela

Affiliations

Soon will be listed here.

Abstract

Liquid biopsies could be considered an excellent diagnostic tool, in different physiological or pathological conditions. The possibility of using liquid biopsies for non-invasive clinical purposes is quite an old idea: indeed many years ago it was already being used in the field of non-invasive prenatal tests (NIPT) for autosomal fetal aneuploidy evaluation. In 1997 Lo et al. had identified fetal DNA in maternal plasma and serum, showing that about 10-15% of cfDNA in maternal plasma is derived from the placenta, and biologic fluid represents an important and non-invasive technique to evaluate state diseases and possible therapies. Nowadays, several body fluids, such as blood, urine, saliva and other patient samples, could be used as liquid biopsy for clinical non-invasive evaluation. These fluids contain numerous and various biomarkers and could be used for the evaluation of pathological and non-pathological conditions. In this review we will analyze the different types of liquid biopsy, their potential role in clinical diagnosis and the functional involvement of extracellular vesicles in these fluids as carriers.

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References

Puche-Sanz I, Rodriguez-Martinez A, Garrido-Navas M, Robles-Fernandez I, Vazquez-Alonso F, Alvarez Cubero M . Liquid biopsy and prostate cancer. Current evidence applied to clinical practice. Actas Urol Esp (Engl Ed). 2019; 44(3):139-147. DOI: 10.1016/j.acuro.2019.08.007. View

Aravanis A, Lee M, Klausner R . Next-Generation Sequencing of Circulating Tumor DNA for Early Cancer Detection. Cell. 2017; 168(4):571-574. DOI: 10.1016/j.cell.2017.01.030. View

Gangoda L, Boukouris S, Liem M, Kalra H, Mathivanan S . Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic?. Proteomics. 2014; 15(2-3):260-71. PMC: 4419270. DOI: 10.1002/pmic.201400234. View

Xue V, Wong C, Cho W . Early detection and monitoring of cancer in liquid biopsy: advances and challenges. Expert Rev Mol Diagn. 2019; 19(4):273-276. DOI: 10.1080/14737159.2019.1583104. View

Caruso S, Poon I . Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris. Front Immunol. 2018; 9:1486. PMC: 6031707. DOI: 10.3389/fimmu.2018.01486. View

Thery C, Witwer K, Aikawa E, Alcaraz M, Anderson J, Andriantsitohaina R . Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2019; 7(1):1535750. PMC: 6322352. DOI: 10.1080/20013078.2018.1535750. View

Johann Jr D, Steliga M, Shin I, Yoon D, Arnaoutakis K, Hutchins L . Liquid biopsy and its role in an advanced clinical trial for lung cancer. Exp Biol Med (Maywood). 2018; 243(3):262-271. PMC: 5813874. DOI: 10.1177/1535370217750087. View

Micanovic R, LaFavers K, Garimella P, Wu X, El-Achkar T . Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis. Nephrol Dial Transplant. 2019; 35(1):33-43. PMC: 8205501. DOI: 10.1093/ndt/gfy394. View

Maas S, Breakefield X, Weaver A . Extracellular Vesicles: Unique Intercellular Delivery Vehicles. Trends Cell Biol. 2016; 27(3):172-188. PMC: 5318253. DOI: 10.1016/j.tcb.2016.11.003. View

10.

Fernandez-Lazaro D, Hernandez J, Garcia A, Cordova Martinez A, Mielgo-Ayuso J, Cruz-Hernandez J . Liquid Biopsy as Novel Tool in Precision Medicine: Origins, Properties, Identification and Clinical Perspective of Cancer's Biomarkers. Diagnostics (Basel). 2020; 10(4). PMC: 7235853. DOI: 10.3390/diagnostics10040215. View

11.

Manga M, Bartram J, Evans B . Economic cost analysis of low-cost sanitation technology options in informal settlement areas (case study: Soweto, Johannesburg). Int J Hyg Environ Health. 2019; 223(1):289-298. DOI: 10.1016/j.ijheh.2019.06.012. View

12.

Russano M, Napolitano A, Ribelli G, Iuliani M, Simonetti S, Citarella F . Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples. J Exp Clin Cancer Res. 2020; 39(1):95. PMC: 7254767. DOI: 10.1186/s13046-020-01601-2. View

13.

Lousada-Fernandez F, Rapado-Gonzalez O, Lopez-Cedrun J, Lopez-Lopez R, Muinelo-Romay L, Suarez-Cunqueiro M . Liquid Biopsy in Oral Cancer. Int J Mol Sci. 2018; 19(6). PMC: 6032225. DOI: 10.3390/ijms19061704. View

14.

Gorges T, Stein A, Quidde J, Hauch S, Rock K, Riethdorf S . Improved Detection of Circulating Tumor Cells in Metastatic Colorectal Cancer by the Combination of the CellSearch® System and the AdnaTest®. PLoS One. 2016; 11(5):e0155126. PMC: 4868337. DOI: 10.1371/journal.pone.0155126. View

15.

Thery C, Zitvogel L, Amigorena S . Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002; 2(8):569-79. DOI: 10.1038/nri855. View

16.

Cirillo M, Craig A, Borchmann S, Kurtz D . Liquid biopsy in lymphoma: Molecular methods and clinical applications. Cancer Treat Rev. 2020; 91:102106. PMC: 8043056. DOI: 10.1016/j.ctrv.2020.102106. View

17.

Zhang X, Ju S, Wang X, Cong H . Advances in liquid biopsy using circulating tumor cells and circulating cell-free tumor DNA for detection and monitoring of breast cancer. Clin Exp Med. 2019; 19(3):271-279. DOI: 10.1007/s10238-019-00563-w. View

18.

Suzuki S, Suzuki J, Kume K, Yoshida K, Suyama H, Kawasaki Y . Poor renal accumulation of 99mTc-DMSA in idiopathic tubular proteinuria. Nephron. 1999; 81(1):49-54. DOI: 10.1159/000045245. View

19.

Sato Y, Matoba R, Kato K . Recent Advances in Liquid Biopsy in Precision Oncology Research. Biol Pharm Bull. 2019; 42(3):337-342. DOI: 10.1248/bpb.b18-00804. View

20.

Tellez-Gabriel M, Heymann M, Heymann D . Circulating Tumor Cells as a Tool for Assessing Tumor Heterogeneity. Theranostics. 2019; 9(16):4580-4594. PMC: 6643448. DOI: 10.7150/thno.34337. View