Simply Adding Oxygen During Hypothermic Machine Perfusion to Combat the Negative Effects of Ischemia-Reperfusion Injury: Fundamentals and Current Evidence for Kidneys

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2021 Aug 27

PMID 34440197

Citations 8

Authors

Tom Darius

Jay Nath

Michel Mourad

Affiliations

Soon will be listed here.

Abstract

The use of high-risk renal grafts for transplantation requires optimization of pretransplant preservation and assessment strategies to improve clinical outcomes as well as to decrease organ discard rate. With oxygenation proposed as a resuscitative measure during hypothermic machine preservation, this review provides a critical overview of the fundamentals of active oxygenation during hypothermic machine perfusion, as well as the current preclinical and clinical evidence and suggests different strategies for clinical implementation.

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