Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons

Overview

Journal Brain Sci

Publisher MDPI

Date 2021 Aug 27

PMID 34439669

Citations 10

Authors

Dmitry B Zorov

Nadezda V Andrianova

Valentina A Babenko

Irina B Pevzner

Vasily A Popkov

Savva D Zorov

Ljubava D Zorova

Egor Yu Plotnikov

Gennady T Sukhikh

Denis N Silachev

Affiliations

Soon will be listed here.

Abstract

There has been an explosion of interest in the use of uncouplers of oxidative phosphorylation in mitochondria in the treatment of several pathologies, including neurological ones. In this review, we analyzed all the mechanisms associated with mitochondrial uncoupling and the metabolic and signaling cascades triggered by uncouplers. We provide a full set of positive and negative effects that should be taken into account when using uncouplers in experiments and clinical practice.

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