Vitreoretinal Lymphoma

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2021 Aug 27

PMID 34439078

Citations 17

Authors

Bianka Sobolewska

Soon-Phaik Chee

Fatma Zaguia

Debra Anne Goldstein

Justine R Smith

Falko Fend

Manabu Mochizuki

Manfred Zierhut

Affiliations

Soon will be listed here.

Abstract

Vitreoretinal lymphoma (VRL) is a rare variant of primary central nervous system lymphoma (PCNSL), mostly of diffuse large B cell lymphoma, which affects the retina and/or the vitreous with or without optic nerve involvement. The disease course is aggressive. Up to 90% of the patients develop central nervous system lymphoma within one year. The diagnosis of VRL is challenging due to nonspecific chronic and relapsing uveitis and is made by anterior chamber tab or vitreous aspirate biopsy. There is no established treatment protocol for VRL patients with bilateral involvement without CNS involvement. There are suggestions to use only intravitreal chemotherapy with methotrexate and/or rituximab. Alternatively, systemic high-dose MTX treatment or external beam radiotherapy is used. Further studies are needed to prove and confirm the prophylactic systemic therapy in preventing CNS involvement in limited VRL.

Citing Articles

Retromode imaging in vitreoretinal lymphoma.

Rivolta M, Cicinelli M, Menean M, Bandello F, Miserocchi E, Marchese A Graefes Arch Clin Exp Ophthalmol. 2024; .

PMID: 39645624 DOI: 10.1007/s00417-024-06703-7.

Personalized treatment approaches in intraocular cancer.

Liu Y, Rokohl A, Guo Y, Yao K, Fan W, Heindl L Adv Ophthalmol Pract Res. 2024; 4(3):112-119.

PMID: 38846623 PMC: 11154118. DOI: 10.1016/j.aopr.2024.03.005.

Case report: Intraretinal hyperflow microinfiltration lesions on swept-source optical coherence tomography angiography as a potential biomarker of primary vitreoretinal lymphoma.

Xu Z, Bai H, Liu X, Shen J, Su Y, Wang Y Front Med (Lausanne). 2024; 11:1386979.

PMID: 38737759 PMC: 11082336. DOI: 10.3389/fmed.2024.1386979.

Multimodal imaging in a case of presumed secondary vitreoretinal lymphoma presenting with inner retina and optic nerve head infiltration.

Levine E, Batra N Am J Ophthalmol Case Rep. 2024; 34:102040.

PMID: 38532849 PMC: 10963182. DOI: 10.1016/j.ajoc.2024.102040.

Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing.

Wang X, Hong J, Xu Y, Zhang P, Li Y, Dou H BMC Ophthalmol. 2024; 24(1):99.

PMID: 38438866 PMC: 10913400. DOI: 10.1186/s12886-024-03334-8.

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