Pharmacokinetic Behaviour of Enrofloxacin After Single Intramuscular Dosage in American Black Vultures ()

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Aug 27

PMID 34439007

Citations 1

Authors

Samanta Waxman

Jose Julio de Lucas

Guillermo Wiemeyer

Laura Torres Bianchini

Manuel Ignacio San Andres

Casilda Rodriguez

Affiliations

Soon will be listed here.

Abstract

The aim of the study was to investigate the intramuscular pharmacokinetics of enrofloxacin in black vultures (). The pharmacokinetics of a single intramuscular dose (10 mg/kg) of enrofloxacin was studied in six vultures. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters were estimated using non-compartmental and compartmental analysis. After intramuscular administration, enrofloxacin showed a rapid and complete absorption, reaching a Cmax value of 3.26 ± 0.23 μg/mL at 1.75 ± 0.53 h. A long terminal half-life of 19.58 h has been observed. Using previously published MIC values to perform a PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 and 125 were 72.93%, 72.34% and 30.86% for and 89.29%, 88.89% and 58.57% for , respectively. Cumulative fraction responses obtained for Cmax/MIC index were 33.93% and 40.18% for and , respectively. The intramuscular administration of 10 mg/kg could be appropriate to treat infectious diseases caused by gram-positive bacteria with MIC value lower than 1 µg/mL; however, although enrofloxacin showed a slow elimination in black vultures, plasma concentrations were insufficient to reach the gram-negative stablished breakpoints.

Citing Articles

Antibiotic Use in Veterinary.

Andres M Antibiotics (Basel). 2022; 11(11).

PMID: 36358194 PMC: 9686639. DOI: 10.3390/antibiotics11111539.

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