Antimicrobial Potential of Microorganisms Isolated from the Bottom Sediments of Lake Baikal

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Aug 27

PMID 34438977

Citations 2

Authors

Olga Babich

Margarita Shevchenko

Svetlana Ivanova

Valery Pavsky

Maria Zimina

Svetlana Noskova

Veronika Anohova

Evgeny Chupakhin

Stanislav Sukhikh

Affiliations

Soon will be listed here.

Abstract

Extremophilic microorganisms attract researchers by their unique characteristics, primarily antagonistic ones, acquired in the process of survival in extreme natural conditions. The antimicrobial potential of the metabolites of these microorganisms is quite broad, from the food industry to therapeutic drugs. Microbial mats of Lake Baikal are a source of unique and diverse microorganisms. The study aimed to evaluate the antimicrobial activity of bacterial strains isolated from the bottom sediments of the lake. Using heterotrophic growth conditions, seven bacterial strains were isolated from samples collected in several coastal zones of Lake Baikal. Thisstudy identified both widespread strains of the genera and and rare genera and . Metabolites of five strains were found to have a broad spectrum of antimicrobial activity. Four large fractions of metabolites of the isolated strains wereidentified. Two peptides of the isolated fractions of metabolites (one is produced by microorganisms of all five isolated strains, another-only by ) are low molecular weight oligopeptides. These peptides were proved to be bacteriocins.

Citing Articles

Genomic Insights into the Bactericidal and Fungicidal Potential of b12.3 Isolated in the Soil of Olkhon Island in Lake Baikal, Russia.

Romanenko M, Shikov A, Savina I, Shmatov F, Nizhnikov A, Antonets K Microorganisms. 2025; 12(12.

PMID: 39770653 PMC: 11676374. DOI: 10.3390/microorganisms12122450.

Antarctic sp. So64.6b showed evolutive divergence within its genus, including new biosynthetic gene clusters.

Nunez-Montero K, Rojas-Villalta D, Barrientos L Front Microbiol. 2022; 13:1007225.

PMID: 36466678 PMC: 9716278. DOI: 10.3389/fmicb.2022.1007225.

Editorial for Special Issue "Alternatives to Antibiotics: Bacteriocins and Antimicrobial Peptides".

Neves J Antibiotics (Basel). 2022; 11(7).

PMID: 35884114 PMC: 9311975. DOI: 10.3390/antibiotics11070860.

References

BAUER A, KIRBY W, SHERRIS J, Turck M . Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966; 45(4):493-6. View

Axenov-Gribanov D, Rebets Y, Tokovenko B, Voytsekhovskaya I, Timofeyev M, Luzhetskyy A . The isolation and characterization of actinobacteria from dominant benthic macroinvertebrates endemic to Lake Baikal. Folia Microbiol (Praha). 2015; 61(2):159-68. DOI: 10.1007/s12223-015-0421-z. View

Imhoff J, Labes A, Wiese J . Bio-mining the microbial treasures of the ocean: new natural products. Biotechnol Adv. 2011; 29(5):468-82. DOI: 10.1016/j.biotechadv.2011.03.001. View

Yu Sherbakov D . Molecular phylogenetic studies on the origin of biodiversity in Lake Baikal. Trends Ecol Evol. 1999; 14(3):92-95. DOI: 10.1016/s0169-5347(98)01543-2. View

Valverde A, Tuffin M, Cowan D . Biogeography of bacterial communities in hot springs: a focus on the actinobacteria. Extremophiles. 2012; 16(4):669-79. DOI: 10.1007/s00792-012-0465-9. View

Rojas J, Martin J, Tormo J, Vicente F, Brunati M, Ciciliato I . Bacterial diversity from benthic mats of Antarctic lakes as a source of new bioactive metabolites. Mar Genomics. 2011; 2(1):33-41. DOI: 10.1016/j.margen.2009.03.005. View

Monciardini P, Iorio M, Maffioli S, Sosio M, Donadio S . Discovering new bioactive molecules from microbial sources. Microb Biotechnol. 2014; 7(3):209-20. PMC: 3992017. DOI: 10.1111/1751-7915.12123. View

Zimina M, Babich O, Prosekov A, Sukhikh S, Ivanova S, Shevchenko M . Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins. Antibiotics (Basel). 2020; 9(9). PMC: 7559574. DOI: 10.3390/antibiotics9090553. View

Terkina I, Driukker V, Parfenova V, Kostornova T . [The biodiversity of actinomycetes in Lake Baikal]. Mikrobiologiia. 2002; 71(3):404-8. View

10.

Maksimenko S, Zemskaia T, Pavlova O, Ivanov V, Buriukhaev S . [Microbial community of the water column of the Selenga River-Lake Baikal biogeochemical barrier]. Mikrobiologiia. 2008; 77(5):660-7. View

11.

Kimura H, Sashihara T, Matsusaki H, Sonomoto K, Ishizaki A . Novel bacteriocin of Pediococcus sp. ISK-1 isolated from well-aged bed of fermented rice bran. Ann N Y Acad Sci. 1999; 864:345-8. DOI: 10.1111/j.1749-6632.1998.tb10336.x. View

12.

Zemskaya T, Cabello-Yeves P, Pavlova O, Rodriguez-Valera F . Microorganisms of Lake Baikal-the deepest and most ancient lake on Earth. Appl Microbiol Biotechnol. 2020; 104(14):6079-6090. DOI: 10.1007/s00253-020-10660-6. View

13.

Brunati M, Rojas J, Sponga F, Ciciliato I, Losi D, Gottlich E . Diversity and pharmaceutical screening of fungi from benthic mats of Antarctic lakes. Mar Genomics. 2011; 2(1):43-50. DOI: 10.1016/j.margen.2009.04.002. View

14.

Sorokin D, Zhilina T, Lysenko A, Tourova T, Spiridonova E . Metabolic versatility of haloalkaliphilic bacteria from soda lakes belonging to the Alkalispirillum-Alkalilimnicola group. Extremophiles. 2006; 10(3):213-20. DOI: 10.1007/s00792-005-0487-7. View

15.

Lomakina A, Pavlova O, Shubenkova O, Zemskaia T . [Diversity of cultured aerobic microorganisms in the areas of natural oil seepage on Lake Baikal]. Izv Akad Nauk Ser Biol. 2009; (5):515-22. View

16.

Belkova N, Parfenova V, Kostopnova T, Denisova L, Zaichikov E . [Microbial biodiversity in the Lake Baikal water]. Mikrobiologiia. 2003; 72(2):239-49. View

17.

Biondi N, Tredici M, Taton A, Wilmotte A, Hodgson D, Losi D . Cyanobacteria from benthic mats of Antarctic lakes as a source of new bioactivities. J Appl Microbiol. 2008; 105(1):105-15. DOI: 10.1111/j.1365-2672.2007.03716.x. View

18.

Trappen S, Mergaert J, van Eygen S, Dawyndt P, Cnockaert M, Swings J . Diversity of 746 heterotrophic bacteria isolated from microbial mats from ten Antarctic lakes. Syst Appl Microbiol. 2003; 25(4):603-10. DOI: 10.1078/07232020260517742. View

19.

Pavlova O, Zemskaia T, Gorshkov A, Kostornova T, Khlystov O, Parfenova V . [Comparative characteristics of microbial communities in two regions of natural oil seepage in Lake Baikal]. Izv Akad Nauk Ser Biol. 2008; (3):333-40. View

20.

Schillinger U, Lucke F . Antibacterial activity of Lactobacillus sake isolated from meat. Appl Environ Microbiol. 1989; 55(8):1901-6. PMC: 202976. DOI: 10.1128/aem.55.8.1901-1906.1989. View