Long-Term Follow-Up of Renal Function in Children After Liver Transplantation-A Single Center Retrospective Study

Overview

Journal Children (Basel)

Specialty Health Services

Date 2021 Aug 27

PMID 34438524

Citations 2

Authors

Grzegorz Kowalewski

Piotr Kalicinski

Marek Stefanowicz

Ryszard Grenda

Piotr Czubkowski

Marek Szymczak

Affiliations

Soon will be listed here.

Abstract

Chronic kidney disease (CKD) is a common complication after liver transplantation (LT). Its prevalence with modern immunosuppression regimens, especially in children, is variable depending on the transplantation era. The study included 61 pediatric patients with at least 10 years of follow-up after liver transplantation remaining under constant care of the Department of Pediatric Surgery and Organ Transplantation. The analysis included several tests: estimated glomerular function (eGFR), results of screening for renal tubular defects and blood concentrations of basic immunosuppressive drug-tacrolimus. CKD was diagnosed in 3% of children at 12 years after LT. The maintaining of tacrolimus concentrations >4 ng/mL in long-term observation was associated with a significant increase of microalbuminuria. The presence of microalbuminuria, regarded as a risk factor of CKD, confirmed the necessity of regular comprehensive assessment of patients in long-term follow-up.

Citing Articles

An innocent bystander or a predisposing culprit? Kidney injury following pediatric liver transplantation.

Glass A, Goldberg O, Mozer-Glassberg Y, Waisbourd-Zinman O, Haskin O, Levi S Pediatr Nephrol. 2024; 40(3):849-857.

PMID: 39320550 DOI: 10.1007/s00467-024-06537-9.

Long-Term Survival and Kidney Function in Pediatric Patients Following Liver Transplantation: A 15-Year Retrospective Cohort Study.

Son R, Suh S, Cho Y, Rhie S Children (Basel). 2022; 9(10).

PMID: 36291480 PMC: 9600481. DOI: 10.3390/children9101544.

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