Birthweight-specific Risk Factors for Necrotising Enterocolitis

Overview

Journal J Epidemiol Community Health

Specialty Health Services

Date 1987 Sep 1

PMID 3443813

Citations 9

Authors

S R Palmer

S J Thomas

R W Cooke

D C Low

W J Fysh

J F Murphy

G M GANDY

H R Gamsu

Affiliations

Soon will be listed here.

Abstract

In a multicentre case-control study of necrotising enterocolitis risk factors were found to vary with birthweight of cases. In very low birthweight cases the risk factors identified were those associated with prolonged or recurrent hypoxia (recurrent apnoea, respiratory distress, assisted ventilation, and umbilical artery catheterisation). In heavier birthweight infants the risk factors were, in contrast, related to hypoxia at birth (low 1 minute Apgar score and endotracheal intubation at birth) and umbilical vessel catheterisation used in exchange transfusions. Contradictory findings in published case-control studies carried out in the USA may be due to differences in patient populations and management policies. Hypoxia and umbilical vessel catheterisation should still be considered as risk factors for necrotising enterocolitis.

Citing Articles

Progress in Research on Stem Cells in Neonatal Refractory Diseases.

Huang F, He Y, Zhang M, Luo K, Li J, Li J J Pers Med. 2023; 13(8).

PMID: 37623531 PMC: 10455340. DOI: 10.3390/jpm13081281.

Necrotizing enterocolitis: controversies and challenges.

Zani A, Pierro A F1000Res. 2016; 4.

PMID: 26918125 PMC: 4753995. DOI: 10.12688/f1000research.6888.1.

A spectrum of intestinal injury models in neonatal mice.

Zani A, Zani-Ruttenstock E, Peyvandi F, Lee C, Li B, Pierro A Pediatr Surg Int. 2015; 32(1):65-70.

PMID: 26552653 DOI: 10.1007/s00383-015-3813-x.

What really causes necrotising enterocolitis?.

Fox T, Godavitarne C ISRN Gastroenterol. 2013; 2012:628317.

PMID: 23316377 PMC: 3534306. DOI: 10.5402/2012/628317.

Epidemiology of necrotizing enterocolitis.

Stoll B Clin Perinatol. 1994; 21(2):205-18.

PMID: 8070222 PMC: 7133385.

References

Yu V, Tudehope D . Neonatal necrotizing enterocolitis: 2. Perinatal risk factors. Med J Aust. 1977; 1(19):688-93. DOI: 10.5694/j.1326-5377.1977.tb131029.x. View

Hackett G, Campbell S, GAMSU H, Pearce J . Doppler studies in the growth retarded fetus and prediction of neonatal necrotising enterocolitis, haemorrhage, and neonatal morbidity. Br Med J (Clin Res Ed). 1987; 294(6563):13-6. PMC: 1245037. DOI: 10.1136/bmj.294.6563.13. View

Bunton G, Durbin G, McIntosh N, Shaw D, Taghizadeh A, Reynolds E . Necrotizing enterocolitis. Controlled study of 3 years' experience in a neonatal intensive care unit. Arch Dis Child. 1977; 52(10):772-7. PMC: 1544786. DOI: 10.1136/adc.52.10.772. View

Kliegman R . Neonatal necrotizing enterocolitis: implications for an infectious disease. Pediatr Clin North Am. 1979; 26(2):327-44. DOI: 10.1016/s0031-3955(16)33709-9. View

Stoll B, KANTO Jr W, Glass R, Nahmias A, Brann Jr A . Epidemiology of necrotizing enterocolitis: a case control study. J Pediatr. 1980; 96(3 Pt 1):447-51. DOI: 10.1016/s0022-3476(80)80696-2. View

Lubin J . A computer program for the analysis of matched case-control studies. Comput Biomed Res. 1981; 14(2):138-43. DOI: 10.1016/0010-4809(81)90031-8. View

Wilson R, KANTO Jr W, McCarthy B, Burton T, Lewin P, Terry J . Epidemiologic characteristics of necrotizing enterocolitis: a population-based study. Am J Epidemiol. 1981; 114(6):880-7. DOI: 10.1093/oxfordjournals.aje.a113258. View

Kliegman R, Hack M, Jones P, Fanaroff A . Epidemiologic study of necrotizing enterocolitis among low-birth-weight infants. Absence of identifiable risk factors. J Pediatr. 1982; 100(3):440-4. DOI: 10.1016/s0022-3476(82)80456-3. View

Wilson R, KANTO Jr W, McCarthy B, Feldman R . Age at onset of necrotizing enterocolitis. Risk factors in small infants. Am J Dis Child. 1982; 136(9):814-6. DOI: 10.1001/archpedi.1982.03970450056013. View

10.

Wilson R, del Portillo M, Schmidt E, Feldman R, KANTO Jr W . Risk factors for necrotizing enterocolitis in infants weighing more than 2,000 grams at birth: a case-control study. Pediatrics. 1983; 71(1):19-22. View

11.

Smith M, Borriello S, Clayden G, Casewell M . Clinical and bacteriological findings in necrotising enterocolitis: a controlled study. J Infect. 1980; 2(1):23-31. DOI: 10.1016/s0163-4453(80)91727-2. View

12.

Yu V, Joseph R, Bajuk B, Orgill A, Astbury J . Perinatal risk factors for necrotizing enterocolitis. Arch Dis Child. 1984; 59(5):430-4. PMC: 1628494. DOI: 10.1136/adc.59.5.430. View

13.

Kosloske A . Pathogenesis and prevention of necrotizing enterocolitis: a hypothesis based on personal observation and a review of the literature. Pediatrics. 1984; 74(6):1086-92. View

14.

KANTO Jr W, Wilson R, Breart G, Zierler S, Purohit D, Peckham G . Perinatal events and necrotizing enterocolitis in premature infants. Am J Dis Child. 1987; 141(2):167-9. DOI: 10.1001/archpedi.1987.04460020057026. View

15.

Book L, Overall Jr J, Herbst J, Britt M, Epstein B, Jung A . Clustering of necrotizing enterocolitis. Interruption by infection-control measures. N Engl J Med. 1977; 297(18):984-6. DOI: 10.1056/NEJM197711032971805. View