Mycotoxin Biomarkers in Pigs-Current State of Knowledge and Analytics

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2021 Aug 26

PMID 34437457

Citations 14

Authors

Agnieszka Tkaczyk

Piotr Jedziniak

Affiliations

Soon will be listed here.

Abstract

Farm animals are frequently exposed to mycotoxins, which have many adverse effects on their health and become a significant food safety issue. Pigs are highly exposed and particularly susceptible to mycotoxins, which can cause many adverse effects. For the above reasons, an appropriate diagnostic tool is needed to monitor pig' exposure to mycotoxins. The most popular tool is feed analysis, which has some disadvantages, e.g., it does not include individual exposure. In recent years, the determination of biomarkers as a method to assess the exposure to mycotoxins by using concentrations of the parent compounds and/or metabolites in biological matrices is becoming more and more popular. This review provides a comprehensive overview of reported in vivo mycotoxin absorption, distribution, metabolism and excretion (ADME) and toxicokinetic studies on pigs. Biomarkers of exposure for aflatoxins, deoxynivalenol, ochratoxin A, fumonisins, T-2 toxin and zearalenone are described to select the most promising compound for analysis of porcine plasma, urine and faeces. Biomarkers occur in biological matrices at trace levels, so a very sensitive technique-tandem mass spectrometry-is commonly used for multiple biomarkers quantification. However, the sample preparation for multi-mycotoxin methods remains a challenge. Therefore, a summary of different biological samples preparation strategies is included in that paper.

Citing Articles

Monitoring Mycotoxin Exposure in Food-Producing Animals (Cattle, Pig, Poultry, and Sheep).

Munoz-Solano B, Lizarraga Perez E, Gonzalez-Penas E Toxins (Basel). 2024; 16(5).

PMID: 38787070 PMC: 11125880. DOI: 10.3390/toxins16050218.

Effects of a Curcumin/Silymarin/Yeast-Based Mycotoxin Detoxifier on Redox Status and Growth Performance of Weaned Piglets under Field Conditions.

Papatsiros V, Papakonstantinou G, Voulgarakis N, Eliopoulos C, Marouda C, Meletis E Toxins (Basel). 2024; 16(4).

PMID: 38668593 PMC: 11054618. DOI: 10.3390/toxins16040168.

HIF-1α is a "brake" in JNK-mediated activation of amyloid protein precursor and hyperphosphorylation of tau induced by T-2 toxin in BV2 cells.

Zhao Y, Valis M, Wang X, Nepovimova E, Wu Q, Kuca K Mycotoxin Res. 2024; 40(2):223-234.

PMID: 38319535 DOI: 10.1007/s12550-024-00525-6.

Effects of a Multi-Component Mycotoxin-Detoxifying Agent on Oxidative Stress, Health and Performance of Sows.

Papatsiros V, Eliopoulos C, Voulgarakis N, Arapoglou D, Riahi I, Sadurni M Toxins (Basel). 2023; 15(9).

PMID: 37756006 PMC: 10537862. DOI: 10.3390/toxins15090580.

Enzymatic degradation of ochratoxin A in the gastrointestinal tract of piglets.

Prasad S, Streit B, Gruber C, Gonaus C J Anim Sci. 2023; 101.

PMID: 37220904 PMC: 10290503. DOI: 10.1093/jas/skad171.

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