Studying Alzheimer Disease, Parkinson Disease, and Amyotrophic Lateral Sclerosis with 7-T Magnetic Resonance

Overview

Journal Eur Radiol Exp

Date 2021 Aug 26

PMID 34435242

Citations 7

Authors

Emrah Duzel

Mauro Costagli

Graziella Donatelli

Oliver Speck

Mirco Cosottini

Affiliations

Soon will be listed here.

Abstract

Ultra-high-field (UHF) magnetic resonance (MR) scanners, that is, equipment operating at static magnetic field of 7 tesla (7 T) and above, enable the acquisition of data with greatly improved signal-to-noise ratio with respect to conventional MR systems (e.g., scanners operating at 1.5 T and 3 T). The change in tissue relaxation times at UHF offers the opportunity to improve tissue contrast and depict features that were previously inaccessible. These potential advantages come, however, at a cost: in the majority of UHF-MR clinical protocols, potential drawbacks may include signal inhomogeneity, geometrical distortions, artifacts introduced by patient respiration, cardiac cycle, and motion. This article reviews the 7 T MR literature reporting the recent studies on the most widespread neurodegenerative diseases: Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.

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