An Overview of the Safety, Efficiency, and Signal Pathways of Stem Cell Therapy for Systemic Lupus Erythematosus

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2021 Aug 26

PMID 34434237

Citations 3

Authors

Qian Yang

Yiping Liu

Guangyong Chen

Wancong Zhang

Shijie Tang

Tianbiao Zhou

Affiliations

Soon will be listed here.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs and tissues. Mesenchymal stem cells (MSCs) are considered a good source for autoimmune disease and hematological disease therapy. This review will summarize the efficacy, safety, and mechanisms of MSC therapy for SLE. MSC therapy can reduce anti-dsDNA, antinuclear antigen (ANA), proteinuria, and serum creatinine in SLE patients. In animal models of SLE, MSC therapy also indicates that it could reduce anti-dsDNA, ANA, proteinuria, and serum creatinine and ameliorate renal pathology. There are no serious adverse events, treatment-related mortality, or tumor-related events in SLE patients after stem cell treatment. MSCs can inhibit inflammatory factors, such as MCP-1 and HMGB-1, and inhibit inflammation-related signaling pathways, such as the NF-B, JAK/STAT, and Akt/GSK3 signaling pathways, to alleviate the lesions in SLE.

Citing Articles

Innovative approaches in stem cell therapy: revolutionizing cancer treatment and advancing neurobiology - a comprehensive review.

Banerjee D, Bhattacharya A, Puri A, Munde S, Mukerjee N, Mohite P Int J Surg. 2024; 110(12):7528-7545.

PMID: 39377430 PMC: 11634158. DOI: 10.1097/JS9.0000000000002111.

Stem cell-based therapy for systemic lupus erythematous.

Moghaddam M, Mousavi M, Ghotloo S J Transl Autoimmun. 2024; 8:100241.

PMID: 38737817 PMC: 11087996. DOI: 10.1016/j.jtauto.2024.100241.

Evaluation of the Therapeutic Potential of Mesenchymal Stem Cells (MSCs) in Preclinical Models of Autoimmune Diseases.

Shandil R, Dhup S, Narayanan S Stem Cells Int. 2022; 2022:6379161.

PMID: 35935180 PMC: 9352490. DOI: 10.1155/2022/6379161.

References

Chang J, Hung S, Wu H, Wu W, Yang A, Tsai H . Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis. Cell Transplant. 2010; 20(2):245-57. DOI: 10.3727/096368910X520056. View

Zhang W, Feng Y, Pang C, Lu F, Wang Y . Transplantation of adipose tissue-derived stem cells ameliorates autoimmune pathogenesis in MRL/lpr mice : Modulation of the balance between Th17 and Treg. Z Rheumatol. 2018; 78(1):82-88. DOI: 10.1007/s00393-018-0450-5. View

Wang D, Niu L, Feng X, Yuan X, Zhao S, Zhang H . Long-term safety of umbilical cord mesenchymal stem cells transplantation for systemic lupus erythematosus: a 6-year follow-up study. Clin Exp Med. 2016; 17(3):333-340. DOI: 10.1007/s10238-016-0427-0. View

Sun L, Akiyama K, Zhang H, Yamaza T, Hou Y, Zhao S . Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells. 2009; 27(6):1421-32. PMC: 2704254. DOI: 10.1002/stem.68. View

Leng X, Jiang Y, Zhou D, Tian X, Li T, Wang S . Good outcome of severe lupus patients with high-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation: a 10-year follow-up study. Clin Exp Rheumatol. 2017; 35(3):494-499. View

Talaulikar D, Tymms K, Prosser I, Smith R . Autologous peripheral blood stem cell transplantation with in vivo T-cell depletion for life threatening refractory systemic lupus erythematosus. Lupus. 2005; 14(2):159-63. DOI: 10.1191/0961203305lu2041cr. View

Ruan G, Yao X, Yang S, Wang J, Shu F, Li Z . Transplanted human umbilical cord mesenchymal stem cells facilitate lesion repair in B6.Fas mice. J Immunol Res. 2015; 2014:530501. PMC: 4352485. DOI: 10.1155/2014/530501. View

Liang J, Zhang H, Hua B, Wang H, Lu L, Shi S . Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis. 2010; 69(8):1423-9. DOI: 10.1136/ard.2009.123463. View

Wang D, Zhang H, Liang J, Wang H, Hua B, Feng X . A Long-Term Follow-Up Study of Allogeneic Mesenchymal Stem/Stromal Cell Transplantation in Patients with Drug-Resistant Systemic Lupus Erythematosus. Stem Cell Reports. 2018; 10(3):933-941. PMC: 5918528. DOI: 10.1016/j.stemcr.2018.01.029. View

10.

Traynor A, Barr W, Rosa R, Rodriguez J, Oyama Y, Baker S . Hematopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patients. Arthritis Rheum. 2002; 46(11):2917-23. DOI: 10.1002/art.10594. View

11.

Meng J, Wang J, Liang W, Qin S, Wu C . Long-term remission after successful pregnancy in autologous peripheral blood stem cell transplanted system lupus erythematosus patients. Rheumatol Int. 2010; 31(5):691-4. DOI: 10.1007/s00296-010-1588-x. View

12.

Li X, Wang D, Liang J, Zhang H, Sun L . Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus. Bone Marrow Transplant. 2012; 48(4):544-50. DOI: 10.1038/bmt.2012.184. View

13.

Smith-Berdan S, Gille D, Weissman I, Christensen J . Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells. Blood. 2007; 110(4):1370-8. DOI: 10.1182/blood-2007-03-081497. View

14.

Gu Z, Akiyama K, Ma X, Zhang H, Feng X, Yao G . Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice. Lupus. 2010; 19(13):1502-14. DOI: 10.1177/0961203310373782. View

15.

Yuan L, Xiao Z, Huang X, Wu M, Shi H, Liu A . Human embryonic mesenchymal stem cells alleviate pathologic changes of MRL/Lpr mice by regulating Th7 cell differentiation. Ren Fail. 2016; 38(9):1432-1440. DOI: 10.3109/0886022X.2015.1136894. View

16.

Gualandi F, Bruno B, Van Lint M, Luchetti S, Uccelli A, Capello E . Autologous stem cell transplantation for severe autoimmune diseases: a 10-year experience. Ann N Y Acad Sci. 2007; 1110:455-64. DOI: 10.1196/annals.1423.048. View

17.

Lin S, Lin W, Liao C, Zhou T . Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants. Stem Cells Int. 2021; 2020:8819757. PMC: 7773456. DOI: 10.1155/2020/8819757. View

18.

Barbado J, Tabera S, Sanchez A, Garcia-Sancho J . Therapeutic potential of allogeneic mesenchymal stromal cells transplantation for lupus nephritis. Lupus. 2018; 27(13):2161-2165. DOI: 10.1177/0961203318804922. View

19.

Schiess M, Suescun J, Doursout M, Adams C, Green C, Saltarrelli J . Allogeneic Bone Marrow-Derived Mesenchymal Stem Cell Safety in Idiopathic Parkinson's Disease. Mov Disord. 2021; 36(8):1825-1834. PMC: 8451899. DOI: 10.1002/mds.28582. View

20.

Li Y, Wang F, Liang H, Tang D, Huang M, Zhao J . Efficacy of mesenchymal stem cell transplantation therapy for type 1 and type 2 diabetes mellitus: a meta-analysis. Stem Cell Res Ther. 2021; 12(1):273. PMC: 8101194. DOI: 10.1186/s13287-021-02342-5. View