Effects of Moxibustion on Reproduction and Metabolism of Polycystic Ovary Syndrome: a Protocol for Meta-analysis and Systematic Review

Overview

Journal BMJ Open

Specialty General Medicine

Date 2021 Aug 26

PMID 34433602

Citations 3

Authors

Kou Xu

Jiajie Wang

Feng Hu

Siying Lv

Yanji Zhang

Qiqi Yang

Wei Huang

Zhongyu Zhou

Affiliations

Soon will be listed here.

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathy in women of reproductive age. Recently, moxibustion, as a complementary and alternative therapy, has been commonly used in assisted reproduction and improvement of metabolic abnormalities in patients with PCOS. Currently, intervention efficacy of the use of moxibustion in PCOS treatment still remains controversial due to lack of high-quality evidence. Consequently, this study protocol was designed to objectively review and evaluate the effectiveness and safety of moxibustion treatment for PCOS.

Methods And Analysis: Electronic searches will be carried out from inception to May 2021 in the online databases of The Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature, Chongqing VIP Chinese Science and Technology Periodical Database (VIP) and China National Knowledge Infrastructure. The Chinese Clinical Trial Registry Center and Clinical Trials will be used for searching ongoing trials. Randomised controlled trials and the first period in randomised cross-over trials involving any type of moxibustion for patients with PCOS will be included. Primary outcomes will be the ovulation rate, pregnancy rate and sex hormone levels, and secondary outcomes will be changes in clinical symptoms and metabolic indicators, total effective rate and the incidences of side effects and adverse events. Briefly, two reviewers will independently conduct study selection and data extraction, and the risk of bias will be assessed. Prior to the formal meta-analysis, the heterogeneity of included studies will be assessed. Review Manager Statistical Software (RevMan) V.5.3 will be used for data processing. Finally, the Grading of Recommendations Assessment, Development and Evaluation method will be applied to evaluate the quality of evidence.

Ethics And Dissemination: Ethical approval is not necessary since this study is designed as a systematic review. This study will be disseminated by a peer-review journal or conference presentation.

Citing Articles

Evaluating the therapeutic potential of moxibustion on polycystic ovary syndrome: a rat model study on gut microbiota and metabolite interaction.

Lin Y, Zeng H, Lin J, Peng Y, Que X, Wang L Front Cell Infect Microbiol. 2024; 14:1328741.

PMID: 38665877 PMC: 11043641. DOI: 10.3389/fcimb.2024.1328741.

Moxibustion prevents tripterygium glycoside-induced oligoasthenoteratozoospermia in rats via reduced oxidative stress and modulation of the Nrf2/HO-1 signaling pathway.

Liang S, Yin Y, Zhang Z, Fang Y, Lu G, Li H Aging (Albany NY). 2024; 16(3):2141-2160.

PMID: 38277193 PMC: 10911353. DOI: 10.18632/aging.205475.

The Application of Complementary and Alternative Medicine in Polycystic Ovary Syndrome Infertility.

Shi Y, Wang Y, Zhu X, Yin R, Ma Y, Han H Evid Based Complement Alternat Med. 2022; 2022:5076306.

PMID: 36248406 PMC: 9568292. DOI: 10.1155/2022/5076306.

References

Zhang T, Wang L, Wang G, Sun J, Mao X, Jiang H . Effects of moxibustion on symptoms of mild cognitive impairment: protocol of a systematic review and meta-analysis. BMJ Open. 2020; 10(4):e033910. PMC: 7213842. DOI: 10.1136/bmjopen-2019-033910. View

Teede H, Misso M, Costello M, Dokras A, Laven J, Moran L . Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Clin Endocrinol (Oxf). 2018; 89(3):251-268. PMC: 9052397. DOI: 10.1111/cen.13795. View

Sutton A, Duval S, Tweedie R, Abrams K, Jones D . Empirical assessment of effect of publication bias on meta-analyses. BMJ. 2000; 320(7249):1574-7. PMC: 27401. DOI: 10.1136/bmj.320.7249.1574. View

Costello M, Shrestha B, Eden J, Sjoblom P, Johnson N . Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome. Cochrane Database Syst Rev. 2007; (1):CD005552. DOI: 10.1002/14651858.CD005552.pub2. View

Yang J, Liu Y, Huang J, Xu J, You X, Lin Q . [Acupuncture and Chinese medicine of artificial cycle therapy for insulin resistance of polycystic ovary syndrome with phlegm damp type and its mechanism]. Zhongguo Zhen Jiu. 2018; 37(11):1163-8. DOI: 10.13703/j.0255-2930.2017.11.007. View

. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004; 81(1):19-25. DOI: 10.1016/j.fertnstert.2003.10.004. View

Azziz R, Carmina E, Chen Z, Dunaif A, Laven J, Legro R . Polycystic ovary syndrome. Nat Rev Dis Primers. 2016; 2:16057. DOI: 10.1038/nrdp.2016.57. View

Chen S, Guo S, Wang J, Ha E, Marmori F, Wang Y . Effectiveness of moxibustion for allergic rhinitis: protocol for a systematic review. BMJ Open. 2015; 5(5):e006570. PMC: 4442239. DOI: 10.1136/bmjopen-2014-006570. View

Yang J, Lin Q, You X, Zhang J, Liu Y, Huang J . [Effect of combined treatment with acupuncture, moxibustion and medication on endometrial receptivity and expression of serum HOXA10 in polycystic ovary syndrome of kidney deficiency and blood stagnation]. Zhongguo Zhen Jiu. 2021; 40(11):1154-8. DOI: 10.13703/j.0255-2930.20191022-k0006. View

10.

Egger M, Davey Smith G, Schneider M, Minder C . Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315(7109):629-34. PMC: 2127453. DOI: 10.1136/bmj.315.7109.629. View

11.

Li R, Zhang Q, Yang D, Li S, Lu S, Wu X . Prevalence of polycystic ovary syndrome in women in China: a large community-based study. Hum Reprod. 2013; 28(9):2562-9. DOI: 10.1093/humrep/det262. View

12.

Liu M, Zhu H, Hu X, Zhu Y, Chen H . Efficacy of different forms of Guizhi Fuling Wan on reproduction and metabolism in women with polycystic ovary syndrome: A protocol for a meta-analysis of randomized controlled trials. Medicine (Baltimore). 2020; 99(44):e22954. PMC: 7598780. DOI: 10.1097/MD.0000000000022954. View

13.

Chen X, Yang D, Li L, Feng S, Wang L . Abnormal glucose tolerance in Chinese women with polycystic ovary syndrome. Hum Reprod. 2006; 21(8):2027-32. DOI: 10.1093/humrep/del142. View

14.

Guyatt G, Oxman A, Akl E, Kunz R, Vist G, Brozek J . GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011; 64(4):383-94. DOI: 10.1016/j.jclinepi.2010.04.026. View

15.

Kwon C, Lee B, Park K . Oriental herbal medicine and moxibustion for polycystic ovary syndrome: A meta-analysis. Medicine (Baltimore). 2018; 97(43):e12942. PMC: 6221674. DOI: 10.1097/MD.0000000000012942. View

16.

Rocca M, Venturella R, Mocciaro R, Di Cello A, Sacchinelli A, Russo V . Polycystic ovary syndrome: chemical pharmacotherapy. Expert Opin Pharmacother. 2015; 16(9):1369-93. DOI: 10.1517/14656566.2015.1047344. View

17.

Nasri H, Rafieian-Kopaei M . Metformin: Current knowledge. J Res Med Sci. 2014; 19(7):658-64. PMC: 4214027. View

18.

. [Chinese guideline for diagnosis and management of polycystic ovary syndrome]. Zhonghua Fu Chan Ke Za Zhi. 2018; 53(1):2-6. DOI: 10.3760/cma.j.issn.0529-567X.2018.01.002. View

19.

Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M . Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015; 4:1. PMC: 4320440. DOI: 10.1186/2046-4053-4-1. View

20.

Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R . Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016; 106(1):6-15. DOI: 10.1016/j.fertnstert.2016.05.003. View