The Role of MiRNA in Cancer: Pathogenesis, Diagnosis, and Treatment

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2021 Aug 25

PMID 34432288

Citations 33

Authors

Erez Uzuner

Gizem Tugce Ulu

Sevim Beyza Gurler

Yusuf Baran

Affiliations

Soon will be listed here.

Abstract

Cancer is also determined by the alterations of oncogenes and tumor suppressor genes. These gene expressions can be regulated by microRNAs (miRNA). At this point, researchers focus on addressing two main questions: "How are oncogenes and/or tumor suppressor genes regulated by miRNAs?" and "Which other mechanisms in cancer cells are regulated by miRNAs?" In this work we focus on gathering the publications answering these questions. The expression of miRNAs is affected by amplification, deletion or mutation. These processes are controlled by oncogenes and tumor suppressor genes, which regulate different mechanisms of cancer initiation and progression including cell proliferation, cell growth, apoptosis, DNA repair, invasion, angiogenesis, metastasis, drug resistance, metabolic regulation, and immune response regulation in cancer cells. In addition, profiling of miRNA is an important step in developing a new therapeutic approach for cancer.

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